Crinone 0.08

Janata Traders (Mfg. by: Merck) · Vaginal Gel

GenericProgesterone Micronized (Vaginal Gel)

Strength0.08

Unit Price

৳ 430

/ 1.125 gm applicator

Order Now

⚠ Disclaimer

The information provided on All Samadhan is intended for general informational purposes only and is prepared based on our best practices. It is not a substitute for professional medical advice, diagnosis, or treatment. While we strive to keep the information accurate and up to date, we do not guarantee its completeness or accuracy. The absence of specific information or warnings about any medicine or service should not be considered as an assurance or endorsement by All Samadhan. All Samadhan shall not be held responsible for any consequences arising from the use of this information. We strongly recommend consulting a qualified healthcare professional or physician for any medical concerns, questions, or clarifications.

Medicine Description

INDICATIONS

Progesterone Micronized is indicated in-

Maintenance of pregnancy in case of Threatened/Recurrent abortion.
Luteal support during IVF and ART.
Luteal support in case of proven luteal phase insufficiency.
Secondary Amenorrhea.
Dysfunctional Uterine Bleeding (DUB).

PHARMACOLOGY

This preparation contains micronized Progesterone which is structurally and biologically identical to natural endogenous progesterone. Progesterone is secreted by the ovary, placenta, and adrenal gland. In the presence of adequate estrogen, progesterone transforms a proliferative endometrium into a secretory endometrium. Progesterone is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo is implanted, progesterone acts to maintain the pregnancy. Progesterone administration decreases the circulatory levels of gonadotropins.

DOSAGE

Route of administration: Vaginal applicationMaintenance of pregnancy in case of Threatened/Recurrent abortion: Use Progesterone Micronized vaginally once daily (90 mg of 8% gel).Reproductive failure and in vitro fertilization treatment: Progesterone Micronized is given at a dose of 90 mg. Treatment is started within 4 days, preferably 2 days, after hCG (human chorionic gonadotropin) administration. One application of Progel 90 mg (8% gel) should be given vaginally daily or twice daily. Most women will respond to 90 mg given daily. However, some women may need 90 mg twice daily. If pregnancy occurs treatment may continue for up to 10 to 12 weeks.Secondary Amenorrhea: Use Progesterone Micronized once a day (90 mg of 8% gel) for every alternative day for 6 days.Use in children and adolescents: Progesterone Micronized is not indicated for use in children.

INTERACTION

Although no interactions with other drugs have been reported, Progel is not recommended for use concurrently with other vaginal preparations.

SIDE EFFECTS

Common side effects: Abdominal pain, perineal pain, constipation, nausea, Diarrhea, vomiting, breast enlargement, dyspareunia, depression, decreased libido, nervousness, and somnolence, intermenstrual bleeding (spotting), vaginal irritation.Rare side effects: cerebrovascular disorders, pulmonary embolism.

PREGNANCY & LACTATION

Pregnancy category A. It has been used to successfully support embryo implantation and maintain pregnancies. Do not use during lactation. Detectable amounts of progestogens have been identified in the milk of mothers receiving them. The effect of this on the nursing infant has not been determined.

PRECAUTIONS & WARNINGS

If cerebrovascular disorders, pulmonary embolism, and retinal thrombosis occurs, the drug should be discontinued immediately. Treatment should be discontinued if the results of liver function tests become abnormal or if cholestatic jaundice appears. Patients with a history of depression should be carefully observed and discontinue the drug if the depression recurs to a serious degree. Progel should not be used concurrently with other vaginal therapy.