VZ-20 20 mg is a Product of the Generic Vonoprazan

What Is VZ-20 20 mg Indications and Uses?

VZ-20 20 mg (Vonoprazan) is indicated for: Gastric ulcer, duodenal ulcer, reflux esophagitis, prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration, prevention of recurrence of gastric or duodenal ulcer during NSAID administration. Adjunct to Helicobacter pylori eradication in the following: Gastric ulcer, duodenal ulcer, gastric mucosa-associated lymphatic tissue (MALT) lymphoma, idiopathic thrombocytopenic purpura, the stomach after endoscopic resection of early-stage gastric cancer or Helicobacter pylori gastritis.

Pharmacology (Source, Chemical and Physical Composition) Of VZ-20 20 mg

VZ-20 20 mg (Vonoprazan) is a potassium competitive acid blocker (P-CAB) and does not require activation by acid. It inhibits H + , K + -ATPase in a reversible and potassium-competitive manner. Vonoprazan has a strong basicity and resides on the acid production site of gastric parietal cells for a long time, thereby inhibiting gastric acid production. Vonoprazan exerts a strong inhibitory effect on formation of mucosal damage in upper part of the gastrointestinal tract.

Side Effects of VZ-20 20 mg

Following side effects have been reported with the use of VZ-20 20 mg (Vonoprazan): Diarrhea, constipation, drug hypersensitivity (including anaphylactic shock), drug eruption, urticaria, hepatotoxicity, jaundice, rash, nausea, abdominal distension, gamma-glutamyl transferase increased, AST increased, Liver function test abnormal, ALT increased, ALP increased, LDH increased, y-GPT increased, edema and eosinophilia

Precautions And Warnings for VZ-20 20 mg

At the treatment, the course of the disease should closely be observed and the minimum therapeutic necessity should be used according to the disease condition. In the long-term, treatment with VZ-20 20 mg (Vonoprazan), close observation by such means as endoscopy should be made. In the maintenance of healing of reflux esophagitis, VZ-20 should be administered only to the patients who repeat recurrence and recrudescence of the condition. Administration to the patients who do not necessitate maintenance of healing should be avoided. When the healing is maintained over a long period and when there is no risk of recurrence, the dose reduction to a dose of 10mg from a dose 20mg, or suspension of administration should be considered.

Use During Pregnancy and Lactation

VZ-20 20 mg (Vonoprazan) should be used in pregnant women or women having possibility of being pregnant only if the expected therapeutic benefit is thought to outweigh any possible risk. It is advisable to avoid the administration of Vonoprazan to nursing mothers. However, when the administration is indispensable, nursing should be discontinued.

Therapeutic Class

Potassium competitive acid blocker

Storage Conditions of It

Store below 30°C, in a cool and dry place. Keep away from light. Keep all the medicine out of the reach of children. Thanks for using MedEx! How would you rate your experience so far?