Valena 0.0001

Incepta Pharmaceuticals Ltd. · Vaginal Cream

GenericEstradiol (vaginal cream)

Strength0.0001

Unit Price

৳ 425

/ 16 gm tube

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The information provided on All Samadhan is intended for general informational purposes only and is prepared based on our best practices. It is not a substitute for professional medical advice, diagnosis, or treatment. While we strive to keep the information accurate and up to date, we do not guarantee its completeness or accuracy. The absence of specific information or warnings about any medicine or service should not be considered as an assurance or endorsement by All Samadhan. All Samadhan shall not be held responsible for any consequences arising from the use of this information. We strongly recommend consulting a qualified healthcare professional or physician for any medical concerns, questions, or clarifications.

Medicine Description

INDICATIONS

Estradiol vaginal cream, 0.01% is indicated in the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.

PHARMACOLOGY

Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol at the receptor level.

DOSAGE

The usual dosage range is 2 to 4 g (marked on the applicator) daily for one or two weeks, then gradually reduced to one half initial dosage for a similar period. A maintenance dosage of 1g, one to three times a week, may be used after restoration of the vaginal mucosa has been achieved.

INTERACTION

Phenobarbital, Carbamazepine, and Rifampin may reduce plasma concentrations of estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile. Erythromycin, Clarithromycin, Ketoconazole, Itraconazole, Ritonavir and Grapefruit juice may increase plasma concentrations of estrogens and may result in side effects.

SIDE EFFECTS

Headache, Breast pain, Irregular vaginal bleeding or spotting, Stomach or abdominal cramps, bloating, Nausea and vomiting, Hair loss, Fluid retention, Vaginal yeast infection. Reactions from inserting ValenaTM Vaginal Cream, such as vaginal burning, irritation, itching etc.

PREGNANCY & LACTATION

Valena should not be used during pregnancy. There appears to be little or no increased risk of birth defects in children born to women who have used estrogens and progestins as an oral contraceptive inadvertently during early pregnancy.

PRECAUTIONS & WARNINGS

Patient taking an additional progestin with Valena may have endometrial hyperplasia which is a precursor to endometrial cancer. These include a possible increased risk of breast cancer. Patients may also face Elevated Blood Pressure, Hypertriglyceridemia (If she has pre-existing hypertriglyceridemia). Caution should be taken for patients who have Hepatic Impairment and/or Past History of Cholestatic Jaundice, Hypothyroidism, Hypocalcemia. Estrogen may cause exacerbation of endometriosis, asthma, diabetes mellitus, epilepsy, migraine or porphyria, systemic lupus erythematosus, and hepatic hemangiomas. So, ValenaTM should be used with caution in women with these conditions.