Urinide 1 mg is a Product of the Generic Bumetanide

Urinide 1 mg belongs to the generic category of Bumetanide. This medicine should be used according to a doctor's advice. We have provided detailed information about the uses, dosage, effectiveness, side effects, precautions, drug interactions, storage conditions, and other important details of Urinide 1 mg. Our goal is to present essential medicine information in one place for patients, caregivers, and healthcare professionals. To better understand Bumetanide and ensure the safe use of this medicine, please read the information below carefully and consult a healthcare professional when necessary.

Description of Urinide 1 mg

Urinide 1 mg may be available as a prescription or over-the-counter medicine, depending on local regulations and medical recommendations. It is used for the treatment and management of specific conditions or symptoms. The way this medicine is used may vary depending on the patient's condition and the advice of a healthcare provider. Detailed information about the approved uses, therapeutic applications, and other relevant details of Urinide 1 mg is provided below to help users gain a clear understanding of this medicine.

What Is Urinide 1 mg Indications and Uses?

Bumetanide is indicated for the treatment of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome.

Pharmacology (Source, Chemical and Physical Composition) Of Urinide 1 mg

Bumetanide is a loop diuretic with a rapid onset and short duration of action. Pharmacological and clinical studies have shown that 1 mg Bumetanide has a diuretic potency equivalent to approximately 40 mg furosemide. The major site of Bumetanide action is the ascending limb of the loop of Henle.Bumetanide inhibits sodium reabsorption in the ascending limb of the loop of Henle. Reabsorption of chloride in the ascending limb is also blocked by Bumetanide.Bumetanide may have an additional action in the proximal tubule. Since phosphate reabsorption takes place largely in the proximal tubule, phosphaturia during Bumetanide induced diuresis is indicative of this additional action. This proximal tubular activity does not seem to be related to an inhibition of carbonic anhydrase. Bumetanide does not appear to have a noticeable action on the distal tubule.

Dosage And Administration of Urinide 1 mg

Oral: 1 mg in the morning, repeated after 6-8 hours if necessary, In severe cases, 5 mg daily increased by 5 mg every 12-24 hours according to response. Elderly, 500 micrograms daily may be sufficient.By IV Injection: 1-2 mg, repeated after 20 minutes if necessary. Elderly, 500 micrograms (1 ml of Bumecard) daily may be sufficient.By IV Infusion: 2-5 mg over 30-60 minutes.Elderly, 500 micrograms (1 ml of Bumecard) daily may be sufficient.By IM Injection: 1 mg initially then adjusted according to response, Elderly 500 micrograms (1 ml of Bumecard) daily may be sufficient.Paediatric use: Safety and effectiveness in paediatric patients below the age of 18 have not been established.

Drug Interactions of Urinide 1 mg

Lithium: Lithium should generally not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.Probenecid: should not be administered concurrently with Bumetanide.Indomethacin: Concurrent therapy with Bumetanide is not recommended.Antihypertensives: Bumetanide may potentiate the effect of various antihypertensive drugs, necessitating a reduction in the dosage of these drugs.Digoxin: Interaction studies in humans have shown no effect on digoxin blood levels.Anticoagulants: Interaction studies in humans have shown Bumetanide to have no effect on warfarin metabolism.

Side Effects of Urinide 1 mg

Muscle cramps (1.1%), dizziness (1.1%), hypotension (0.8%), headache (0.6%), nausea (0.6%) Others (ECG changes (0.4 %), musculoskeletal pain (0.2 %), Abdominal pain (0.2 %), renal failure (0.1%), thrombocytopenia (0.2%) etc.

Use During Pregnancy and Lactation

Pregnancy Category C. There are no adequate and well controlled studies in pregnant woman. It is not known wheather this drug is excreted in human milk.

Precautions And Warnings for Urinide 1 mg

Serum potassium should be measured periodically and potassium supplements or potassium sparing diuretics added if necessary.

Use In Special Populations

Paediatric use: Safety and effectiveness in paediatric patients below the age of 18 have not been established.

Therapeutic Class

Loop diuretics

Storage Conditions of It

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.