Trazzo 100 mg is a Product of the Generic Trazodone Hydrochloride

What Is Trazzo 100 mg Indications and Uses?

Trazzo 100 mg (Trazodone Hydrochloride) tablets are indicated for the treatment of major depressive disorder (MDD) in adults.

Pharmacology (Source, Chemical and Physical Composition) Of Trazzo 100 mg

The mechanism of Trazzo 100 mg (Trazodone Hydrochloride)’s antidepressant action is not fully understood, but is thought to be related to its enhancement of serotonergic activity in the CNS. Trazodone is both a selective serotonin reuptake inhibitor (SSRI) and a 5HT2 receptor antagonist and the net result of this action on serotonergic transmission and its role in trazodone’s antidepressant effect is unknown.

Dosage And Administration of Trazzo 100 mg

An initial dose of 150 mg/day in divided doses is suggested. The dosage should be initiated at a low-dose and increased gradually, noting the clinical response and any evidence of intolerance. Occurrence of drowsiness may require the administration of a major portion of the daily dose at bedtime or a reduction of dosage. The dose may be increased by 50 mg/day every 3 to 4 days. The maximum dose for outpatients usually should not exceed 400 mg/day in divided doses. Inpatients (i.e., more severely depressed patients) may be given up to but not in excess of 600 mg/day in divided doses. Once an adequate response has been achieved, dosage may be gradually reduced, with subsequent adjustment depending on therapeutic response.

Drug Interactions of Trazzo 100 mg

CNS Depressants: Trazzo 100 mg (Trazodone Hydrochloride) tablets may enhance effects of alcohol, barbiturates, or other CNS depressants. CYP3A4 Inhibitors: Consider Trazzo tablets dose reduction based on tolerability. CYP3A4 Inducers: Increase in Trazzo tablets dosage may be necessary. Digoxin or Phenytoin: Monitor for increased digoxin or phenytoin serum levels. Warfarin: Monitor for increased or decreased prothrombin time.

Side Effects of Trazzo 100 mg

Most common adverse reactions (incidence ≥5% and twice that of placebo) are: edema, blurred vision, syncope, drowsiness, fatigue, diarrhea, nasal congestion, weight loss.

Precautions And Warnings for Trazzo 100 mg

Serotonin Syndrome : Increased risk when co-administered with other serotonergic agents (e.g., SSRI, SNRI, triptans), but also when taken alone. If it occurs, discontinue Trazzo 100 mg (Trazodone Hydrochloride) tablets and initiate supportive treatment. Cardiac Arrhythmias : Increases the QT interval. Avoid use with drugs that also increase the QT interval and in patients with risk factors for prolonged QT interval. Orthostatic Hypotension and Syncope : Warn patients of risk and symptoms of hypotension. Increased Risk of Bleeding : Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk. Priapism : Cases of painful and prolonged penile erections and priapism have been reported. Immediate medical attention should be sought if signs and symptoms of prolonged penile erections or priapism are observed. Activation of Mania or Hypomania : Screen for bipolar disorder and monitor for mania or hypomania. Potential for Cognitive and Motor Impairment : Has potential to impair judgment, thinking, and motor skills. Advise patients to use caution when operating machinery. Angle-Closure Glaucoma : Avoid use of antidepressants, including Trazzo tablets, in patients with untreated anatomically narrow angles.

Use During Pregnancy and Lactation

Advise patients to notify their healthcare provider if they become pregnant or intend to become pregnant during therapy with Trazzo 100 mg (Trazodone Hydrochloride) tablets. Advise patients that there is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to trazodone hydrochloride tablets during pregnancy. Data from published literature report the transfer of trazodone into human milk. There are no data on the effect of trazodone on milk production. Limited data from postmarketing reports have not identified and association of adverse effects on the breastfed child. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for trazodone hydrochloride and any potential adverse effects on the breastfed child from trazodone hydrochloride or from the underlying maternal condition.

Therapeutic Class

SSRIs & related anti-depressant drugs

Storage Conditions of It

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children. Pack Images: Trazzo 100 mg Tablet Thanks for using MedEx! How would you rate your experience so far?