OTC

Topril 50 mg

Jayson Pharmaceutical Ltd. · Tablet

GenericCaptopril

Strength50 mg

Total Strip5

Strip Size10

Unit Price

৳ 2

/ Piece

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The information provided on All Samadhan is intended for general informational purposes only and is prepared based on our best practices. It is not a substitute for professional medical advice, diagnosis, or treatment. While we strive to keep the information accurate and up to date, we do not guarantee its completeness or accuracy. The absence of specific information or warnings about any medicine or service should not be considered as an assurance or endorsement by All Samadhan. All Samadhan shall not be held responsible for any consequences arising from the use of this information. We strongly recommend consulting a qualified healthcare professional or physician for any medical concerns, questions, or clarifications.

Medicine Description

INDICATIONS

Mild-to-moderate hypertension: As an adjunct to thiazide therapy in patients who have not responded effectively to thiazide treatment alone.Severe hypertension: Where standard therapy has failed.Congestive heart failure: Captopril is indicated for the treatment of congestive heart failure. The drug should be used together with diuretics and where appropriate, digitalis.

PHARMACOLOGY

Captopril is a sulfhydryl-containing analog of proline with antihypertensive activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. Approxiately 60-75% of an oral dose of captopril is repidly absorbed from the GI tract in fasting healthy individuals or hypertensive patients. More than 95% of a dose is excreted renally, both as unchanged (45-50%) drug and as metabolites.

DOSAGE & ADMINISTRATION

Mild-to-moderate hypertension: The initial dose is 12.5 mg twice daily. The usual maintenance dose is 25mg twice daily which can be increased incrementally, at two to four week intervals, until a satisfactory response is achieved, to a maximum of 50 mg twice daily.Severe hypertension: In severe hypertension the starting dose is 12.5 mg b.d. The dosage may be increased incrementally to a maximum of 50 mg t.d.s.Heart failure: A starting dose of 6.25mg or 12.5mg may minimise a transient hypotensive effect. The usual maintenance dose is 25mg three times a day. The usual maximum dose is 150 mg daily.Captopril must be taken 1 hour before meals to ensure maximum absorption.Use in Child: Safety and effectiveness in pediatric patients have not been established.

INTERACTION

Do not coadminister aliskiren with Captopril in patients with diabetes. Monitor renal function periodically.

SIDE EFFECTS

Neutropenia, anaemia, proteinuria, hypotension, tachycardia, rashes, usually pruritic may occur. Gastric irritation and abdominal pain may occur.

PREGNANCY & LACTATION

There are no available data in pregnant women to inform the drug-associated risk. Because of the potential for serious adverse reactions a decision should be made whether to discontinue nursing or to discontinue the drug.

PRECAUTIONS & WARNINGS

Evaluation of the patient should include assessment of renal function before Captopril therapy and at appropriate intervals thereafter. Patients with renal impairment should not normally be treated with Captopril. Captopril should not be used in patients with aortic stenosis or outflow tract obstruction.