Spotclen Plus 40 mg+80 mg+30 mg+20 mg

Spotclen Plus 40 mg+80 mg+30 mg+20 mg | INDICATIONS AND USES

This combination cream is indicated-

For the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines and other unwanted areas of melanin hyperpigmentation.
To reduce hyperpigmentation caused by photosensitization associated with inflammation or with the use of certain cosmetics.

Spotclen Plus 40 mg+80 mg+30 mg+20 mg | PHARMACOLOGY

Hydroquinone is a topical depigmentating agent used in hyperpigmentation conditions by suppressing melanocyte metabolic processes. It also increases melanin excretion from melanocytes and prevents its production.Octyldimethyl P-aminobenzoate is used topically as a sunscreen. It is used to prevent sunburn, but unlikely to prevent drug-related or other photosensitivity reactions associated with UVA light.Dioxybenzone (benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. It is a derivative of benzophenone. It is a yellow powder with a melting point of 68 °C. It is insoluble in water, but moderately soluble in ethanol and isopropanol.Oxybenzone: Although benzophenones are primarily UV-B absorbers, oxybenzone absorbs well through UV-A II. Oxybenzone can be considered a broad-spectrum absorber. It significantly augments UV-B protection when used in a given formula.

Spotclen Plus 40 mg+80 mg+30 mg+20 mg | DOSAGE & ADMINISTRATION

Adult: This cream should be applied to the affected area and rubbed in well twice daily or as directed by a physician. Most discolorations begin to lighten after 3 or 4 weeks of treatment but it may take longer. After desired bleaching, use only as needed to maintain results of treatment. After reduction of hyperpigmentation, use of sunscreen agents and/or protective clothing should continue on bleached skin to prevent repigmentation.Children: Safety and efficacy in paediatric patients below the age of 12 years have not been established.

Spotclen Plus 40 mg+80 mg+30 mg+20 mg | DRUG INTERACTIONS

Peroxide: Concurrent use of peroxide may result in transient dark staining of skin areas due to oxidation of hydroquinone.

Spotclen Plus 40 mg+80 mg+30 mg+20 mg | SIDE EFFECTS

No systemic adverse reactions have been reported. Occasional hypersensitivity (localized contact dermatitis) may occur in which case the medication should be discontinued.

Spotclen Plus 40 mg+80 mg+30 mg+20 mg | USE DURING PREGNANCY AND LACTATION

It is not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used in pregnant woman only when clearly indicated. It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother.

Spotclen Plus 40 mg+80 mg+30 mg+20 mg | PRECAUTIONS & WARNINGS

Hydroquinone is a skin bleaching agent which may produce unwanted cosmetic effects if not used as directed. The physician should be familiar with the contents of this insert before prescribing or dispensing this medication.Test for skin sensitivity before using by applying a small amount to an unbroken patch of skin to check in 24 hours. Minor redness is not a contraindication, but where there is itching or vesicle formation or excessive inflammatory response, further treatment is not advised. If no bleaching or lightening effect is noted after 2 months of treatment, the medication should be discontinued.Contact with the eyes and lips should be avoided. Hydroquinone should not be applied to cut or abraded skin.

Spotclen Plus 40 mg+80 mg+30 mg+20 mg | THERAPEUTIC CLASS

Sunblock Preparation

Spotclen Plus 40 mg+80 mg+30 mg+20 mg | STORAGE CONDITIONS

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.