Rifamax 20 mg/ml is a Product of the Generic Rifaximin

What Is Rifamax 20 mg/ml Indications and Uses?

Rifamax 20 mg/ml (Rifaximin) is indicaed in- Treatment of traveler's diarrhea by noninvasive strains of E. coli reduction in risk of overt hepatic encephalopathy bacterial overgrowth of irritable bowel syndrome.

Pharmacology (Source, Chemical and Physical Composition) Of Rifamax 20 mg/ml

Rifamax 20 mg/ml (Rifaximin) is a semisynthetic, rifamycin-based non-systemic antibiotic. Very little of the drug will pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. Rifaximin inhibits bacterial RNA synthesis by its action on the beta-subunit of the DNA-dependent RNA polymerase. It shows the same broad spectrum activity as rifamycin which exerts bactericidal action against many species of Gram-positive and Gram-negative, aerobic and anaerobic bacteria.

Dosage And Administration of Rifamax 20 mg/ml

Travelers' Diarrhea : The recommended dose of Rifamax 20 mg/ml (Rifaximin) is one 200 mg tablet taken orally three times a day for 3 days. Hepatic Encephalopathy : The recommended dose of Rifaximin is one 550 mg tablet taken orally two times a day. Irritable Bowel Syndrome with Diarrhea : The recommended dose of Rifaximin is one 550 mg tablet taken orally three times a day for 14 days. Patients who experience a recurrence of symptoms can be retreated up to two times with the same dosage regimen.

Drug Interactions of Rifamax 20 mg/ml

In an in vitro study has suggested that Rifamax 20 mg/ml (Rifaximin) induces CYP3A4. However, in patients with normal liver function, Rifamax at the recommended dosing regimen is not expected to induce CYP3A4.

Side Effects of Rifamax 20 mg/ml

Side effects include flatulence, headache, abdominal pain, rectal tenesmus, defecation urgency, nausea, constipation, pyrexia, vomiting. Reactions have been reported, including anaphylaxis, angioneurotic edema, and exfoliative dermatitis.

Precautions And Warnings for Rifamax 20 mg/ml

Rifamax 20 mg/ml (Rifaximin) is not found to be effective in patients with diarrhea complicated by fever and/or blood in the stools. Rifamax therapy should be discontinued if diarrhea symptoms get worse or persist for more than 24-48 hours and alternative antibiotic therapy should be considered. Pseudomembranous colitis has been reported with nearly all antibacterial agents and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents.

Use During Pregnancy and Lactation

Pregnancy category C. It is not known whether Rifamax 20 mg/ml (Rifaximin) is excreted in human milk or not.

Therapeutic Class

4-Quinolone preparations

Storage Conditions of It

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children. Thanks for using MedEx! How would you rate your experience so far?