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Copyright © All Samadhan - Operated by M/S. Genius Experts | All Rights Reserved
DBID
Registration ID: 176322642
Trade License: TRAD/DNCC/040904/2023
Copyright © All Samadhan - Operated by M/S. Genius Experts | All Rights Reserved
DBID
Registration ID: 176322642
Trade License: TRAD/DNCC/040904/2023
Renata PLC · Metered-Dose Inhaler (MDI)
/ 120 metered doses
The information provided on All Samadhan is intended for general informational purposes only and is prepared based on our best practices. It is not a substitute for professional medical advice, diagnosis, or treatment. While we strive to keep the information accurate and up to date, we do not guarantee its completeness or accuracy. The absence of specific information or warnings about any medicine or service should not be considered as an assurance or endorsement by All Samadhan. All Samadhan shall not be held responsible for any consequences arising from the use of this information. We strongly recommend consulting a qualified healthcare professional or physician for any medical concerns, questions, or clarifications.
This combination is indicated for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.
This preparation contains two bronchodilators: Glycopyrronium is a long-acting muscarinic antagonist (LAMA) and Formoterol is a long-acting β2-adrenergic agonist (LABA) with a rapid onset of action. Glycopyrronium has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of the M3 receptor at the smooth muscle leading to bronchodilation. Formoterol causes direct relaxation of airway smooth muscle as a consequence of the increase in cyclic AMP through activation of adenylyl cyclase.
Adults: Should be administered as 2 puffs twice daily, in the morning and in the evening.Use in patients with severe renal impairment should be considered if the potential benefit of the treatment outweighs the risk.
Other adrenergic drugs may potentiate efect. Use with caution.
Xanthine derivatives, steroids, diuretics or non-potassium sparing diuretics may potentiate hypokalemia or EDG changes. Use with caution.
Diuretics: Use with caution.
Monoamine oxidase inhibitors and tricyclic antidepressants: Use with extreme caution. May potentiate efect of formoterol fumarate on cardiovascular system.
Beta-Blockers: Use with caution and only when medically necessary.
Anticholinergics: May interact additively with concomitantly used anticholinergic medications. Avoid administrations of this combination with other anticholinergic-containing drugs.
The most common adverse reactions include cough and urinary tract infection. Possible side effects are sudden breathing problems, headache, tremor, nervousness, rash, swelling of the face, mouth and tongue, hives, increase blood pressure, chest pain, irregular heartbeat, muscle spasm, muscle weakness, eye pain or discomfort and urinary retention.
There are no data on the use of this preparation in pregnant women.
This combination should not be used with an additional medicine containing a LABA because of risk of overdose.
Not indicated for the relief of acute bronchospasm
Do not initiate in acutely deteriorating COPD or to treat acute symptoms
If paradoxical bronchospasm occurs, discontinue this combination and institute alternative therapy
Use with caution in patients with cardiovascular disorders
Use with patients with convulsive disorders, thyrotoxicosis, diabetes mellitus and ketoacidosis.
Be alert to hypokalemia and hyperglycemia
Worsening of narrow angle glaucoma may occur. Use with caution with patients with narrow-angle glaucoma
Worsening of urinary retention may occur. Use with caution with patients with prostatic hyperplasia or bladder-neck obstruction
Do not store above 30°C. Do not expose to temperatures higher than 50°C. Do not pierce the pressurized container. Keep out of the reach of the children.