Regenox 0.05

INDICATIONS

Minoxidil topical solution is indicated for the treatment of-

Male androgenetic alopecia (male pattern hair loss) on the top of the scalp (vertex).
Female androgenetic alopecia (female pattern hair loss) on the top of the scalp.

PHARMACOLOGY

Minoxidil topical solution has been shown to stimulate hair growth in males with androgenetic alopecia. The basic change in androgenetic alopecia is the conversion of terminal, non-vellus hair to vellus hair, i.e., hair which is thinner, shorter and less pigmented. Although the exact mechanism of action of Minoxidil in the treatment of androgenetic alopecia is not known, there may be more than one mechanism by which Minoxidil topical solution stimulates hair growth; they include:

vasodilation of the micro circulation around the hair follicles which may stimulate hair growth;
direct stimulation of the hair follicle cells to enter into a proliferative phase;
resting phase (telogen); follicles being stimulated to pass into growth phase (anagen) follicles.

DOSAGE & ADMINISTRATION

Minoxidil 2% Solution: A total dose of 1 mL (7 sprays) Minoxidil topical 2% solution (20 mg Minoxidil) should be applied twice per day to the scalp, beginning at the center of the affected area. This dose should be used regardless of the size of the affected area. The total daily dose should not exceed 2 mL (40 mg Minoxidil). Suitable for men and women use.Minoxidil Topical 5% Solution: Apply 1 mL (7 sprays) 2 times a day directly onto the scalp in the hair loss area. It should be used for men only.

INTERACTION

Minoxidil topical solution should not be used along with other topical agents known to alter the stratum corneum barrier such as tretinoin or dithranol, due to the enhanced absorption of Minoxidil. Although there is no clinical evidence, there exists the theoretical possibility of absorbed Minoxidil potentiating orthostatic hypotension caused by peripheral vasodilators.

SIDE EFFECTS

Colds and respiratory infections
Rhinitis
Sinusitis
Coughing
Scaling
Itching
Rash

PREGNANCY & LACTATION

Systemically absorbed Minoxidil is secreted in human milk. There are no adequate and well controlled studies in pregnant women. Animal studies have shown a risk to the fetus at exposure levels that are very high compared to those intended for human exposure.

PRECAUTIONS & WARNINGS

Minoxidil topical solution is for external use only. Apply only to scalp. Before applying this solution, the user should determine that the scalp is normal and healthy. Hands should be washed thoroughly after use. Inhalation of the spray should be avoided. This solution contains ethanol (alcohol), which will cause burning and irritation of the eye. In the event of accidental contact with sensitive surfaces (eye, abraded skin, mucous membranes), the area should be bathed with large amounts of cool tap water.

THERAPEUTIC CLASS

Other scalp preparations

STORAGE CONDITIONS

Do not store above 30°C temperature. Keep away from light and wet place. Keep out of reach of children.