Pylotrip R 20 mg+1000 mg+500 mg is a Product of the Generic Rabeprazole + Amoxicillin + Clarithromycin

What Is Pylotrip R 20 mg+1000 mg+500 mg Indications and Uses?

This combination is indicated for the eradication of H. pylori in active chronic gastric, duodenal and gastric ulcers.

Pharmacology (Source, Chemical and Physical Composition) Of Pylotrip R 20 mg+1000 mg+500 mg

Amoxicillin is similar to penicillin in its bactericidal action against susceptible bacteria during the stage of active multiplication. It acts through the inhibition of cell wall biosynthesis that leads to the death of the bacteria.Clarithromycin acts by inhibiting microsomal protein synthesis in susceptible organisms mainly by binding to the donor site on the 50S subunit of the bacterial ribosome and preventing translocation to that site.Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+,K+ ATPase at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion.

Dosage And Administration of Pylotrip R 20 mg+1000 mg+500 mg

Each strip twice daily for 7 days. In case of severity, each strip twice daily for 14 days.Geriatric patients: Elderly patients may suffer from asymptomatic renal and hepatic dysfunction. Care should be taken when administering to these patients.

Drug Interactions of Pylotrip R 20 mg+1000 mg+500 mg

Clarithromycin use in patients who are receiving theophylline may be associate with increase of serum theophylline concentrations. There have been reports of interactions of clarithromycin with carbamazepine, cyclosporine, tacrolimus, hexobarbital, phenytoin, alfetanil, disopyramide, lovastatin, bromocriptine, valproate,terfenadine, cisapride, pimozide & astemizole.

Side Effects of Pylotrip R 20 mg+1000 mg+500 mg

Adverse reactions which were reported as possibly or probably related to treatment (<3%) in clinical trials when all three components of this therapy were given concomitantly are listed below and divided by body systems. Digestive system: Nausea, vomiting, diarrhoea, dark stools, dry mouth, glossitis, oral moniliasis, stomatitis, tongue discolorationMusculoskeletal system: MyalgiaNervous System: Confusion, headache, dizzinessSkin: Skin reactionsUrogenital System: Vaginitis, vaginal moniliasis.

Use During Pregnancy and Lactation

This should be used during pregnancy only if the potential benefit justifies the potential risk of the mother. Amoxicillin is excreted in human milk in very small amounts. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug therapy, taking into account the importance of the therapy to the mother.

Precautions And Warnings for Pylotrip R 20 mg+1000 mg+500 mg

Serious and occasionally fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on Amoxicillin therapy. These reactions are more appropriate to occur in individuals with a history of penicillin hypersensitivity. Clarithromycin should not be used in pregnant women except in clinical circumstances where no alternative therapy is appropriate.

Therapeutic Class

Anti H. pylori drugs

Storage Conditions of It

Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.