Palimax ER Tablet (Extended Release) XR Tablet 1.5 mg is a Product of the Generic Paliperidone

What Is Palimax ER Tablet (Extended Release) XR Tablet 1.5 mg Indications and Uses?

Palimax ER extended release tablet is indicated for- Schizophrenia, including acute treatment and recurrence prevention Treatment of schizoaffective disorder as monotherapy and in combination with antidepressants or mood stabilizers

Pharmacology (Source, Chemical and Physical Composition) Of Palimax ER Tablet (Extended Release) XR Tablet 1.5 mg

Palimax ER Tablet (Extended Release) XR Tablet 1.5 mg (Paliperidone) is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives. Paliperidone is the major active metabolite of Risperidone. It is a centrally active dopamine Type 2 (D2) antagonist and with predominant serotonin Type 2 (5-HT2A) antagonist activity. It is also active as an antagonist at α1 and α2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. It has no affinity for cholinergic muscarinic or β1-and β2-adrenergic receptors.

Dosage And Administration of Palimax ER Tablet (Extended Release) XR Tablet 1.5 mg

Schizophrenia : Adults: Initial dose is 6 mg/day. Recommended dose is 3-12 mg/day, Maximum dose is 12 mg/day Adolescents (Weight <51kg): Initial dose is 3 mg/day, Recommended dose is 3-6 mg/day, Maximum dose is 6 mg/day Adolescents (Weight ≥51kg): Initial dose is 3 mg/day, Recommended dose is 3-12 mg/day, Maximum dose is 12 mg/day Schizoaffective disorder : adults Initial dose is 6 mg/day. Recommended dose is 3-12 mg/day, Maximum dose is 12 mg/day. Palimax ER Tablet (Extended Release) XR Tablet 1.5 mg (Paliperidone) extended release tablet can be taken with or without food. It must be swallowed whole with the aid of liquids. Tablets should not be chewed, divided or crushed.

Drug Interactions of Palimax ER Tablet (Extended Release) XR Tablet 1.5 mg

Palimax ER should be used with caution in combination with other centrally acting drugs and alcohol. It may antagonize the effect of Levodopa and other dopamine agonists. Because of its potential for inducing orthostatic hypotension, an additive effect may be observed when Palimax ER is administered with other therapeutic agents that have this potential. Strong CYP3A4/P-glycoprotein (P-gp) inducers: It may be necessary to increase the dose of Palimax ER when a strong inducer of both CYP3A4 and P-gp (e.g., carbamazepine) is co-administered. Conversely, on discontinuation of the strong inducer, it may be necessary to decrease the dose of Palimax ER. Co-administration of divalproex sodium increased Cmax and AUC of Palimax ER by approximately 50%. Adjust dose of Palimax ER if necessary based on clinical assessment.

Side Effects of Palimax ER Tablet (Extended Release) XR Tablet 1.5 mg

The most common adverse reactions of Palimax ER are tachycardia, akathisia, somnolence, tremor, dystonia, cogwheel rigidity, anxiety, weight increased, dyspepsia, constipation, nasopharyngitis etc.

Precautions And Warnings for Palimax ER Tablet (Extended Release) XR Tablet 1.5 mg

Caution should be exercised when Palimax ER is prescribed in patients with known Cardiovascular diseases, QT prolongation, Neuroleptic malignant syndrome, Tardive dyskinesia, Hyperglycemia, Dyslipidemia, Obesity, Hyperprolactinemia, Leukopenia, Neutropenia, Agranulocytosis, Seizures, Potential for Cognitive & Motor impairment etc.

Use During Pregnancy and Lactation

Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Palimax ER Tablet (Extended Release) XR Tablet 1.5 mg (Paliperidone) should be used during pregnancy only if the potential benefits justifies the potential risk to the fetus. Paliperidone is excreted in human breast milk. The known benefits of breastfeeding should be weighed against the unknown risks of infant exposure to Paliperidone.

Therapeutic Class

Atypical neuroleptic drugs

Storage Conditions of It

Store in a cool and dry place, away from light. Keep out of reach of children. Pack Image: Palimax ER 1.5 mg XR Tablet Thanks for using MedEx! How would you rate your experience so far?