Olixar 20 mg is a Product of the Generic Olanzapine

What Is Olixar 20 mg Indications and Uses?

Olixar 20 mg (Olanzapine) is indicated for the acute and maintenance treatment of schizophrenia and related psychoses where positive symptoms (e.g. delusions, hallucinations, disordered thinking, hostility and suspiciousness) and/or negative symptoms (e.g. flattened affect, emotional and social withdrawal, poverty ... Read more Olixar 20 mg (Olanzapine) is indicated for the acute and maintenance treatment of schizophrenia and related psychoses where positive symptoms (e.g. delusions, hallucinations, disordered thinking, hostility and suspiciousness) and/or negative symptoms (e.g. flattened affect, emotional and social withdrawal, poverty of speech) are prominent. Olixar is indicated for the treatment of acute manic or mixed episodes in bipolar disorder, with or without psychotic features and with or without a rapid cycling course

Pharmacology (Source, Chemical and Physical Composition) Of Olixar 20 mg

Olixar 20 mg (Olanzapine) is an antipsychotic agent and has affinities for serotonin 5HT2A/2C, 5HT3, 5HT6; dopamine D1, D2, D3, D4, D5; cholinergic muscarinic receptors M1-M5; α1 adrenergic; and histamine H1 receptors. The mechanism of action of Olanzapine, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug’s efficacy in schizophrenia is mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism. Olanzapine is well absorbed after oral administration, reaching peak plasma concentrations within 5 to 8 hours. The absorption is not affected by food. Olanzapine is not mutagenic or clastogenic as well as not carcinogenic.

Drug Interactions of Olixar 20 mg

Olixar 20 mg (Olanzapine) may antagonize the effects of levodopa and dopamine agonists. Drugs that induce CYP1A2 or glucoronyl transferase enzymes e.g, Omeprazole and Rifampicin, may increase Olixar clearance. Inhibitors of CYP1A2 may potentially inhibit Olixar elimination. Carbamazepine may increase the clearance of Olixar. Concomitant administration of activated charcoal reduces the oral bioavailability of Olixar by 50-60%. Caution should be taken when Olixar is administered with centrally acting drugs and alcohol.

Side Effects of Olixar 20 mg

Very common undesirable effects are somnolence and weight gain. Besides increased appetite, elevated glucose levels, elevated triglyceride levels, dizziness, akathisia, Parkinson's disease, dyskinesia, orthostatic hypotension, mild and transient anticholinergic effects including constipation and dry mouth, asthenia, edema and photosensitivity reaction etc. may be observed.

Precautions And Warnings for Olixar 20 mg

Olixar 20 mg (Olanzapine) should be used cautiously in patients who have a history of seizures or have conditions associated with seizures. Olixar should be used cautiously in patients with low leukocyte and/or neutrophil counts for any reason, drug induced bone marrow depression/toxicity caused by radiation therapy or chemotherapy, hypereosinophilic conditions, impaired hepatic function, and patients using hepatotoxic medicines, centrally acting drug and medicines know to increase QT interval, especially in the elderly. Patients should be cautioned about operating hazardous machinery, including motor vehicles.

Use During Pregnancy and Lactation

Olixar 20 mg (Olanzapine) should be used in pregnancy only if the potential benefits justify the potential risk to the foetus. So, patients should be advised to notify their physician if they become pregnant or intend to become pregnant during treatment with Olanzapine. There is no report to show teratogenecity. Patients should not breast feed if they are taking Olanzapine.

Therapeutic Class

Atypical neuroleptic drugs

Storage Conditions of It

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children. Pack Image: Olixar 20 mg Tablet Thanks for using MedEx! How would you rate your experience so far?