Nortin 25 mg

Nortin 25 mg | INDICATIONS AND USES

Nortriptyline is indicated in Depressive illness, Panic disorder & Neuropathic pain.

Nortin 25 mg | PHARMACOLOGY

Nortriptyline, a dibenzocycloheptadiene tricyclic antidepressant, is the primary active metabolite of amitriptyline. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin.

Nortin 25 mg | DOSAGE & ADMINISTRATION

Depression, low dose initially increased as necessary to 75-100 mg daily in divided doses or as a single dose (max. 150 mg daily); Adolescent and Elderly patient: 30-50 mg daily in divided doses. Neuropathic pain, initially 10 mg daily at night, gradually increased if necessary to 75 mg daily; higher doses under specialist supervision. Or as directed by the physician.

Nortin 25 mg | DRUG INTERACTIONS

Administration of reserpine during therapy with a tricyclic antidepressant has been shown to produce a "stimulating" effect in some depressed patients. Close supervision and careful adjustment of the dosage are required when Nortriptyline is used with other anticholinergic drugs and sympathomimetic drugs. Concurrent administration of cimetidine and tricyclic antidepressants can produce clinically. A case of significant hypoglycemia has been reported in a type II diabetic patient maintained on chlorpropamide (250 mg/day), after the addition of nortriptyline (125 mg/day).

Nortin 25 mg | SIDE EFFECTS

Dry mouth, Constipation, Blurred vision, Tremor, Sedation, Sweating, Rashes, Behavioral disturbances.

Nortin 25 mg | USE DURING PREGNANCY AND LACTATION

Pregnancy category C. Nortriptyline should only be used in pregnancy if considered necessary, taking into account the risks of untreated depression, and under the close supervision of a physician.

Nortin 25 mg | PRECAUTIONS & WARNINGS

Nortriptyline should be used with caution in patients with cardiovascular disease, including heart failure, or arrhythmias. Cardiovascular and ECG monitoring should be undertaken in such patients. When given in high doses patient have been reported to produce QTc prolongation, arrhythmias, sinus tachycardia, and prolongation of the conduction time. Myocardial Infarction and stroke have also been reported with medicines of this class.

Nortin 25 mg | THERAPEUTIC CLASS

Tricyclic & related anti-depressant drugs, Tricyclic Anti-depressant

Nortin 25 mg | STORAGE CONDITIONS

Store in a cool and dry place & protect from light. Keep out of the reach of the children.