Nikethamide 250 mg/ml

Nikethamide 250 mg/ml | INDICATIONS AND USES

Nikethamide is indicated in-

Acute respiratory failure
Respiratory depression following anesthesia
CNS depression

Nikethamide 250 mg/ml | PHARMACOLOGY

Nikethamide also known as nicotinic acid diethylamide is a central & respiratory stimulant. It has direct stimulatory action on CNS, increases the frequency & depth of breathing. It has no immediate impact on the cardiovascular system. It is extensively metabolized in liver. All metabolites & a small amount of unchanged drug is excreted in urine.

Nikethamide 250 mg/ml | DOSAGE & ADMINISTRATION

2 to 10 mL by slow IV injection of the usual 25% solution every 20 to 30 minutes if necessary. Infants and children are particularly susceptible to toxic effects of nikethamide.

Nikethamide 250 mg/ml | DRUG INTERACTIONS

Anesthetic, sympathomimetics, MAOIs, neuromuscular blockers, bupropion.

Nikethamide 250 mg/ml | SIDE EFFECTS

Dyspnoea, respiratory problems such as coughing bronchospasm. Other CNS side effects include convulsion, headache & dizziness. Cardiovascular side effects inlude Iteration of blood pressure & cardiac arrhythmia. Over dosage may cause nausea, vomiting & diarrhoea.

Nikethamide 250 mg/ml | USE DURING PREGNANCY AND LACTATION

There are no enough adequate and controlled studies in pregnant women and nursing mothers.

Nikethamide 250 mg/ml | PRECAUTIONS & WARNINGS

It should not used in less severe degrees of hypertension or impaired cardiac reverse & hepatic dysfunction.

Nikethamide 250 mg/ml | THERAPEUTIC CLASS

Respiratory stimulants: analeptics

Nikethamide 250 mg/ml | STORAGE CONDITIONS

Store below 25°C in a dry place, away from light.