Nifin Tablet (Sustained Release) SR Tablet 10 mg is a Product of the Generic Nifedipine

What Is Nifin Tablet (Sustained Release) SR Tablet 10 mg Indications and Uses?

Nifin is a specific and potent calcium-channel blocker with peripheral and coronary vasodilator properties. It reduces peripheral resistance, after load and blood pressure. It is used in the prophylaxis and treatment of angina, Raynauds phenomenon, ischaemic heart disease, hypertension and heart failure.

Pharmacology (Source, Chemical and Physical Composition) Of Nifin Tablet (Sustained Release) SR Tablet 10 mg

Nifin Tablet (Sustained Release) SR Tablet 10 mg (Nifedipine) is an inhibitor of Calcium Channel Blocker that blocks the transmembrane influx of Calcium ions into muscle cells. Nifedipine has selective effects as a dilator of arterial vessels. Nifedipine dilates main coronary and systemic arteries. As a result blood pressure falls and this elicits a sympathetic reflex response causing tachycardia and an increased cardiac output. Pulmonary arterial pressure also falls. Nifedipine has direct negative inotropic effects on cardiac muscles and these effects are seen at higher doses than dose which causes arterial vasodilatation.

Dosage And Administration of Nifin Tablet (Sustained Release) SR Tablet 10 mg

The starting dose for patients not previously prescribed Nifin Tablet (Sustained Release) SR Tablet 10 mg (Nifedipine) products, is one tablet once daily. The recommended dose in hypertension and angina prophylaxis is 20 mg twice daily during or after food. Dosage may be adjusted within the range 10 mg twice daily to 40 mg twice daily. Patients with liver dysfunction should commence therapy with 10 mg twice daily with careful monitoring. Patients with renal impairment do not require adjustment of dosage.

Drug Interactions of Nifin Tablet (Sustained Release) SR Tablet 10 mg

ACE inhibitors: Enhanced hypotensive effect. Anti-arrythmics: Plasma concentration of quinidine is reduced. Anti-bacterials: Rifampicin possibly increases metabolism of Nifin. Anti-epileptics: Plasma concentration of phenytoin increases. Antipsychotics: Enhanced hypotensive effect. β-blockers: Occasionally severe hypotension and heart failure may occur. Cyclosporin: Plasma concentration of Nifin possibly increases. Muscle relaxants: Effect of muscle relaxants e.g. tubocurarine increases. Antiulcerants: Metabolism of Nifin increased.

Side Effects of Nifin Tablet (Sustained Release) SR Tablet 10 mg

Headache, flushing, lethargy, gravitational oedema rash, nausea, increased frequency of micturation, eye pain, gum hyperplasia, depression, tremor, photosensitivity and few cases of jaundice have been reported. These reactions may regress on discontinuation of therapy. Its introduction may induce attacks of ischaemic pain in some patients with angina pectoris.

Precautions And Warnings for Nifin Tablet (Sustained Release) SR Tablet 10 mg

Tablets should be swallowed whole and should not be bitten, chewed or broken up. It should be used with caution in patient whose cardiac reserve is poor. Should be withdrawn if ischaemic pain occurs or existing pain worsens shortly after initiating treatment. Use in diabetic patients requires adjustment of their control. Since the absorption of the drug could be modified by renal disease, caution should be exercised in treating such patients.

Use During Pregnancy and Lactation

There are no adequate and well controlled studies in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Therapeutic Class

Calcium-channel blockers

Storage Conditions of It

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children. Thanks for using MedEx! How would you rate your experience so far?