Neural 500 mcg is a Product of the Generic Mecobalamin

What Is Neural 500 mcg Indications and Uses?

Mecobalamin tablet is indicated in-

Peripheral neuropathy
Diabetic neuropathy
Alcoholic neuropathy
Drug induced neuropathy
Entrapment neuropathy
Lumbago
Intercostal neuralgia
Diabetic retinopathy
Multiple sclerosis
Vertebral syndrome
Parkinson's disease
Alzheimar's disease
Bell's palsy

Mecobalamin Injection is indicated in-

The treatment of peripheral neuropathies megaloblastic anemia due to vitamin B12 deficiency.

Pharmacology (Source, Chemical and Physical Composition) Of Neural 500 mcg

Mecobalamin is one of the two coenzyme forms of vitamin B12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. It is a cofactor in the enzyme methionine synthase which functions to transfer methyl groups for the regeneration of methionine from homocysteine. It is required for integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis. Mecobalamin helps in the synthesis of neuronal lipids, regeneration of axonal nerves, promotes axonal transport and has neuroprotective activity.

Dosage And Administration of Neural 500 mcg

Tablet: 0.5 mg tablet 3 times daily after meal. The dosage should be adjusted according to age of patient’s and the severity of the symptoms.Injection:

Peripheral Neuropathies: Adult: 1 ampoule (Mecobalamin 500 mcg) daily, administered IM or IV 3 times a week. The dose may be adjusted depending on the patient's age and symptoms.
Megaloblastic Anemia: Adult: 1 ampoule (Mecobalamin 500 mcg) daily, administered IM or IV 3 times a week. After 2 months of medication, the dose should be reduced to a single administration of 1 ampoule at 1 to 3 month intervals for maintenance therapy.

Use in Children: Not Recommended.

Drug Interactions of Neural 500 mcg

Absorption of vitamin B12 from the gastrointestinal tract may be reduced by neomycin, aminosalicylic acid, histamine H2-antagonists, omeprazole, and colchicine. Serum concentrations may be decreased by use of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations.

Side Effects of Neural 500 mcg

Dermatologic Effects: Rash; In the event of such symptoms, treatment should be discontinued.Gastrointestinal Effects: Anorexia, nausea/vomiting and diarrhea.Neurologic Effects (Central nervous system): Headache.Others:

Anaphylactoid reaction: decrease in blood pressure or dyspnea, may occur. Patients should be carefully observed. In the event of such symptoms, treatment should be discontinued immediately and appropriate measures taken.
Hot sensation
Diaphoresis
Pain/induration at the site of intramuscular injection

Use During Pregnancy and Lactation

There are no data available for mecobalamin to be used in pregnant women & lactating mother. However, since vitamin B12 is distributed into breast milk, The American Academy of Pediatrics considers its use to be usually compatible with breast feeding.

Precautions And Warnings for Neural 500 mcg

This product should not be used aimlessly for more than one month unless it is effective. The prolonged use of larger doses of Mecobalamin is not recommended for patients whose occupation requires the handling of mercury or mercury compounds.

Therapeutic Class

Drugs for Megaloblastic Anemia

Storage Conditions of It

Store at room temperature. Protect from moisture and light.