Neocafen 20 mg/ml

Neocafen 20 mg/ml | INDICATIONS AND USES

Caffeine Citrate is indicated for the treatment of apnea of prematurity.

Neocafen 20 mg/ml | PHARMACOLOGY

Caffeine is structurally related to other methylxanthines, theophylline and theobromine. It is a bronchial smooth muscle relaxant, a CNS stimulant, a cardiac muscle stimulant and a diuretic. Although the mechanism of action of caffeine in apnea of prematurity is not known, several mechanisms have been hypothesized. These include:

stimulation of the respiratory center,
increased minute ventilation,
the decreased threshold to hypercapnia,
increased response to hypercapnia,
increased skeletal muscle tone,
decreased diaphragmatic fatigue,
increased metabolic rate,
increased oxygen consumption.

Most of these effects have been attributed to antagonism of adenosine receptors, both A1 and A2 subtypes, by caffeine

Neocafen 20 mg/ml | DOSAGE & ADMINISTRATION

Loading Dose: Dose of Caffeine Citrate-20 mg/kg. Route-Intravenous infusion (over 30 minutes) by using a syringe infusion pump. Frequency- One Time.Maintenance Dose: Dose of Caffeine Citrate-5 mg/kg. Route-Intravenous infusion (over 10 minutes) by using a syringe infusion pump. Frequency-Every 24 hours (beginning 24 hours after the loading dose).The duration of treatment of apnea of prematurity in the clinical trial was limited to 10 to 12 days. The safety and efficacy of caffeine citrate for longer periods of treatment have not been established. Vials containing visible particulate matter should be discarded. For single use only. Any unused solution should be discarded.

Neocafen 20 mg/ml | DRUG INTERACTIONS

Few data exist on drug interactions with caffeine in preterm neonates. Based on adult data, lower doses of caffeine may be needed following co-administration of drugs which are reported to decrease caffeine elimination (e.g., cimetidine and ketoconazole) and higher caffeine doses may be needed following co-administration of drugs that increase caffeine elimination (e.g., phenobarbital and phenytoin). Inter-conversion between caffeine and theophylline has been reported in preterm neonates. The concurrent use of these drugs is not recommended.

Neocafen 20 mg/ml | SIDE EFFECTS

Few cases of sepsis, hemorrhage, necrotizing enterocolitis, gastritis, gastrointestinal hemorrhage, acidosis, cerebral hemorrhage, dyspnea, lung edema, dry skin, rash, skin breakdown, kidney failure were reported.

Neocafen 20 mg/ml | USE DURING PREGNANCY AND LACTATION

Pregnancy Category C. Caffeine is excreted into breast milk. Breast-feeding mothers of newborn infants treated with Caffeine Citrate should not ingest caffeine-containing foods, beverages or medicinal products containing caffeine.

Neocafen 20 mg/ml | PRECAUTIONS & WARNINGS

Caffeine Citrate should be used with caution in infants with seizure disorders, cardiovascular disease and impaired renal or hepatic function. Serum concentrations of caffeine should be monitored and dose administration of Caffeine Citrate should be adjusted to avoid toxicity in this population.

Neocafen 20 mg/ml | THERAPEUTIC CLASS

Painkiller Muscle Relaxant

Neocafen 20 mg/ml | STORAGE CONDITIONS

Do not store above 30°C. Keep away from light and out of the reach of children.