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DBID
Registration ID: 176322642
Trade License: TRAD/DNCC/040904/2023
Copyright © All Samadhan - Operated by M/S. Genius Experts | All Rights Reserved
DBID
Registration ID: 176322642
Trade License: TRAD/DNCC/040904/2023
Drug International Ltd. · Nasal Spray
/ 120 metered spray
The information provided on All Samadhan is intended for general informational purposes only and is prepared based on our best practices. It is not a substitute for professional medical advice, diagnosis, or treatment. While we strive to keep the information accurate and up to date, we do not guarantee its completeness or accuracy. The absence of specific information or warnings about any medicine or service should not be considered as an assurance or endorsement by All Samadhan. All Samadhan shall not be held responsible for any consequences arising from the use of this information. We strongly recommend consulting a qualified healthcare professional or physician for any medical concerns, questions, or clarifications.
Xylometazoline is indicated in-
Nasal congestion in colds, rhinitis, sinusitis, headache.
Tubal block and serous otitis media associated with nasal congestion.
Nasal congestion is caused by various etiologies, such as rhinosinusitis and allergic or non-allergic rhinitis, leading to congestion of the venous sinusoids lining the nasal mucosa. Activation of α-adrenergic receptors leads to vasoconstriction of the blood vessels of the nasal mucosa and resumption of nasal airflow. As the most abundantly expressed in the human nasal mucosa, α1A- and α2B-adrenoceptors may play the most important role in vasoconstriction of the human nasal mucosa. Xylometazoline is a more selective agonist at α2B-adrenoceptors, with affinity at α1A-, α2A-, α2C-, α1B-, and α1D-adrenoceptors. Xylometazoline decreases nasal resistance during inspiration and expiration and increases the volume of nasal airflow. Compared to oxymetazoline, another imidazoline nasal decongestant, xylometazoline had a slightly faster onset of action although they had a similar duration of action. In one study, subjects with nasal congestion reported relief of earache and sore throat in addition to nasal decongestion: it is speculated that oxymetazoline mediates this effect by causing vasoconstriction of the nasal mucosa that contains the venous sinuses and nasal decongestion allows breathing through the nose, providing relief from sore throat caused by mouth breathing that dries and irritates the throat.
Nasal Drop-
Adults: 0.1%: 2 or 3 drops in each nostril two to three times daily. 0.1% should not be used for children under the age of 12 years.
Children 6 to 12 years of age: 0.05%: 2 or 3 drops in each nostril two or three times daily.
Children less than 6 years of age: 0.05%: 1 drop in each nostril two or three times daily.
Infants less than 3 months: Not to be used in infants less than 3 months.
Nasal Spray-
Children from 2-12 years old: 0.05%: 1 spray, per nostril not more often than three times per day.
Adults and adolescents (over 12 years of age): 0.1%: 1 spray into each nostril, 1 to 3 times daily as needed. Do not exceed 3 applications daily into each nostril. Or, as directed by the registered physician.
No drug interactions have been reported.
The following side-effects have occasionally been encountered:
A burning sensation in the nose and throat
Local irritation
Nausea and dryness of the nasal mucosa.
Pregnancy category C. Xylometazoline should not be used during pregnancy. The use of Otrivin while breastfeeding should only take place on the instructions of a doctor.
Xylometazoline Hydrochloride nasal drops for adults (0.1%) should not be used for children below 12 years. Drops should not be used for long time in cases with chronic rhinitis. Prolonged use of the drops may cause rebound congestion and drug induced rhinitis.
Nasal Anti-histamine preparations
Protect from light. For reasons of hygiene, do not use the bottle more than 28 days after opening it.