Loradale Tablet (Extended Release) XR Tablet 10 mg+240 mg is a Product of the Generic Loratadine + Pseudoephedrine

What Is Loradale Tablet (Extended Release) XR Tablet 10 mg+240 mg Indications and Uses?

This tablet should be administered when both the antihistaminic properties of Loradale Tablet (Extended Release) XR Tablet 10 mg+240 mg (Loratadine + Pseudoephedrine) and the nasal decongestant activity of Pseudoephedrine are desired. This is indicated for the relief of the following symptoms due to hay fever or other upper respiratory allergies: nasal congestion runny nose sneezing itchy, watery eyes itching of the nose or throat swelling of nasal passages sinus congestion and pressure

Pharmacology (Source, Chemical and Physical Composition) Of Loradale Tablet (Extended Release) XR Tablet 10 mg+240 mg

Loradale Tablet (Extended Release) XR Tablet 10 mg+240 mg (Loratadine + Pseudoephedrine) is a non-sedative histamine H1-receptor antagonist with anti-allergic properties. Loratadine is a long acting tricyclic anti-histamine with selective peripheral H1-receptor antagonistic activity and no central sedative or anti-cholinergic effect. Pseudoephedrine is an orally active sympathomimetic amine and exerts a decongestant action on the nasal mucosa. This is recognized as an effective agent for the relief of nasal congestion due to allergic rhinitis. It has nasal and bronchial decongestant activity. Pseudoephedrine is both an α-and β-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of α-adrenergic receptors of the respiratory mucosa. It also directly stimulates β-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.

Drug Interactions of Loradale Tablet (Extended Release) XR Tablet 10 mg+240 mg

This tablet is contraindicated in patients taking monoamino oxidase (MAO) inhibitors and for 2 weeks after stopping use of an MAO inhibitor. The antihypertensive effects of beta-adrenergic blocking agents, methyldopa, reserpine and veaturm alkaloids may be reduced by sympathomimetics. Increased ectopic pacemaker activity can occur when Pseudoephedrine is used concomitantly with digitalis. Concomitantly administration of Erythromycin, Ketoconazole and Cimetidine increases plasma concentration of both Loradale Tablet (Extended Release) XR Tablet 10 mg+240 mg (Loratadine + Pseudoephedrine) and Decarboethoxyloratadine. But there were no clinically relevant changes in the safety profile of Loratadine.

Side Effects of Loradale Tablet (Extended Release) XR Tablet 10 mg+240 mg

In general it is well tolerated. Clinical trial suggests a very low of adverse effects commonly reported is dry mouth, somnolence, insomnia, pharyngitis, dizziness, coughing, fatigue, nausea, nervousness, anorexia, dysmenorrheal and headache. Other less common side effects may include; increased sweating, thirst, back pain, chest pain, malaise, palpitations, hypertension, tachycardia, abdominal distension, altered taste, flatulence, myalgia, dry throat, agitation, micturation frequency etc.

Precautions And Warnings for Loradale Tablet (Extended Release) XR Tablet 10 mg+240 mg

This tablet should generally be avoided in patients with hepatic insufficiency. Patients with renal insufficiency should be given a lower initial dose because they have reduced clearance of Loradale Tablet (Extended Release) XR Tablet 10 mg+240 mg (Loratadine + Pseudoephedrine) and Pseudoephedrine. As because the doses of this fixed combination product cannot be individually titrated and hepatic insufficiency results in a reduced clearance of Loratadine to a much greater extent than Pseudoephedrine. This tablet should be used with caution in patients with hypertension, diabetes mellitus, ischemic heart disease, increased intraocular pressure, hyperthyroidism, renal impairment, or with accompanying hypotension may be produced by sympathomimetic amines.

Use During Pregnancy and Lactation

Pregnancy category B: no evidence of risk in human is reported. It is not known if this combination product is excreted in human milk. However, both Loradale Tablet (Extended Release) XR Tablet 10 mg+240 mg (Loratadine + Pseudoephedrine) and Pseudoephedrine when administered alone passed into breast milk, so it should not be administered to lactating mothers.

Therapeutic Class

Anti-histamine

Storage Conditions of It

Store at a cool and dry place, away from light. Keep out of the reach of children. Thanks for using MedEx! How would you rate your experience so far?