Lomebac Ophthalmic Solution Eye Drop 0.003 is a Product of the Generic Lomefloxacin

What Is Lomebac Ophthalmic Solution Eye Drop 0.3% Indications and Uses?

Lomebac is indicated for bacterial infections, including bacterial conjunctivitis, blepharitis, and blepharo-conjunctivitis which are due to Lomebac susceptible germs. It is also indicated for the treatment of keratitis and corneal ulcer.

Pharmacology (Source, Chemical and Physical Composition) Of Lomebac Ophthalmic Solution Eye Drop 0.3%

Lomebac Ophthalmic Solution Eye Drop 0.3% (Lomefloxacin) is a difluorinated quinolone. It is bactericidal with a broad spectrum of antibacterial activity. Lomefloxacin interferes with bacterial DNA related processes like initiation, elongation, and termination phases of replication, transcription, DNA repair, recombination, transposition, supercoiling and relaxation of DNA. The target molecule for quinolones is the subunit of bacterial enzyme gyrase (topoisomerase II). The forming of a stable complex between the quinolone and the whole gyrase tetramer A2B2 leads to impaired enzyme functions, resulting in a rapid killing of sensitive bacteria. Plasmid mediated transfer of resistance has not been observed so far. Cross-resistance has only been reported with other quinolones, but not with any other group of antibiotics.

Dosage And Administration of Lomebac Ophthalmic Solution Eye Drop 0.3%

Adults and children (above 1 year of age): Instill one drop 2 times daily into the lower conjunctival sac. At the beginning of treatment, application should be more frequent, apply 5 drops within 20 minutes or 1 drop every hour during 6 -10 hours.

Drug Interactions of Lomebac Ophthalmic Solution Eye Drop 0.3%

In order to avoid reduction of efficacy, no ophthalmic preparations containing heavy metals, such as zinc, should be used during 15 minutes preceding and following application of the eye drops

Side Effects of Lomebac Ophthalmic Solution Eye Drop 0.3%

Slight and transient burning immediately after instillation of the eye drops has been reported in 4.7% of users. Although phototoxicity has not been reported after ophthalmic use, photosensitization is possible. Since the following allergic reactions have been reported after systemic use of Lomebac, they can not be excluded after topical ophthalmic use: allergic reactions, asthma, dyspnoea, urticaria, erythema, pruritus, and hypersensitization.

Precautions And Warnings for Lomebac Ophthalmic Solution Eye Drop 0.3%

Lomebac eye drops contains Benzalkonium Chloride as a preservative, which can permeate into soft hydrophilic contact lenses. For this reason soft hydrophilic contact lenses should be taken out before applying Lomebac eye drops, and be replaced after 15 minutes.

Use During Pregnancy and Lactation

Animal studies have revealed that after systemic use, Lomebac Ophthalmic Solution Eye Drop 0.3% (Lomefloxacin) passes the placental barrier and is also excreted in maternal milk. Clinical studies on the use of Lomefloxacin eye drops during human pregnancy or lactation are not available. The drug therefore, should only be used when the potential benefit to the pregnant/lactating woman outweighs the potential risk to the fetus or the infant.

Therapeutic Class

4-Quinolone preparations, Ophthalmic antibacterial drugs

Storage Conditions of It

Store at below 30°C in a dry place protected from light. It is desirable that the contents should not be used more than one month after first opening of the bottle. Pack Image: Lomebac 0.3% Eye Drop Thanks for using MedEx! How would you rate your experience so far?