Initer IV/SC 5000 IU is a Product of the Generic Erythropoietin Alfa

What Is Initer IV/SC 5000 IU Indications and Uses?

Initer is an erythropoiesis-stimulating agent (ESA) indicated for: Treatment of anemia due to: Chronic Kidney Disease (CKD) in patients on dialysis and not on dialysis. Zidovudine in HIV-infected patients. The effects of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy. ... Read more Initer is an erythropoiesis-stimulating agent (ESA) indicated for: Treatment of anemia due to: Chronic Kidney Disease (CKD) in patients on dialysis and not on dialysis. Zidovudine in HIV-infected patients. The effects of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy. Reduction of allogeneic RBC transfusions in patients undergoing elective, noncardiac, nonvascular surgery. Prevention of anemia of prematurity in infants with a birth weight of 750 to 1500 gm and gestational age of less than 34 weeks.

Drug Interactions of Initer IV/SC 5000 IU

There are no known clinically significant drug interactions but the effect of Initer may be potentiated by the simultaneous therapeutic administration of a haematinic agent such as ferrous sulphate when a deficiency state exists.

Side Effects of Initer IV/SC 5000 IU

Adverse reactions in 5% of Initer treated patients in clinical studies were: Patients with CKD: Hypertension, arthralgia, muscle spasm, pyrexia, dizziness, medical device malfunction, vascular occlusion, and upper respiratory tract infection. Zidovudine-treated HIV-infected Patients: Pyrexia, cough, rash, and injection site irritation. Cancer Patients on Chemotherapy: Nausea, vomiting, myalgia, arthralgia, stomatitis, cough, weight decrease, leukopenia, bone pain, rash, hyperglycemia, headache, depression, dysphagia, hypokalemia, and thrombosis. Surgery Patients: Nausea, vomiting, pruritus, headache, injection site pain, chills, deep vein thrombosis, cough, and hypertension. Premature infants: A fall in serum ferritin values is very common (>10%)

Use During Pregnancy and Lactation

There are no adequate and well-controlled studies in pregnant women. Studies in animals have shown reproduction toxicology. Consequently: In chronic renal failure patients, Initer IV/SC 5000 IU (Erythropoietin Alfa) should be used in pregnancy only if the potential benefit outweighs the potential risk to the foetus. In pregnant or lactating surgical patients participating in an autologous blood predonation programme, the use of Erythropoietin alfa is not recommended. It is not known whether exogenous Erythropoietin alfa is excreted in human milk. Erythropoietin alfa should be used with caution in nursing women. A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy with Erythropoietin alfa should be made taking into account the benefit of breast feeding to the child and the benefit of Erythropoietin alfa therapy to the woman.

Therapeutic Class

Drugs for Haemolytic Hypoplastic & Renal Anemia

Storage Conditions of It

Store at 2ºC to 8ºC. Do not freeze or shake. This temperature range should be closely maintained until administration to the patient. Store in original package in order to protect from light. Pack Image: Initer 5000 IU Injection Thanks for using MedEx! How would you rate your experience so far?