Griso Ultra 125 mg is a Product of the Generic Griseofulvin [Ultra Microsize]

What Is Griso Ultra 125 mg Indications and Uses?

Ultramicrosize is indicated for the treatment of the following tinea infections; tinea corporis onychomycosis tinea pedis tinea cruris tinea barbae tinea capitis etc.

Pharmacology (Source, Chemical and Physical Composition) Of Griso Ultra 125 mg

Griso Ultra 125 mg (Griseofulvin [Ultra Microsize]) is an orally active antibiotic derived from a species of Penicillium which is used to treat tinea infections. Griseofulvin has a fungistatic effect by its ability to disrupt the mitotic spindle structure of the fungal cell which arrests metaphase in cell division. After oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions. The efficiency of gastrointestinal absorption of ultramicrocrystalline griseofulvin is approximately one and one-half times that of the conventional microsize griseofulvin. This factor permits the oral intake of two-thirds as much ultramicrocrystalline griseofulvin as the microsize form. However, there is currently no evidence that this lower dose confers any significant clinical differences with regard to safety and/or efficacy.

Drug Interactions of Griso Ultra 125 mg

There have been reports in the literature of possible interactions between Griso Ultra 125 mg (Griseofulvin [Ultra Microsize]) and oral contraceptives. The effect of alcohol may be potentiated by Griso Ultra, producing such effects as tachycardia and flush.

Side Effects of Griso Ultra 125 mg

Side effects reported occasionally are oral thrush, nausea, vomiting, epigastric distress, diarrhea, headache, fatigue, dizziness, insomnia, mental confusion, and impairment of performance of routine activities. Proteinuria and leukopenia have been reported rarely.

Precautions And Warnings for Griso Ultra 125 mg

Patients on prolonged therapy with any potent medication should be under close observation. Periodic monitoring of organ system function, including renal, hepatic and hematopoietic, should be done. Since Griso Ultra 125 mg (Griseofulvin [Ultra Microsize]) is derived from species of Penicillium, the possibility of cross sensitivity with penicillin exists; however, known penicillin-sensitive patients have been treated without difficulty. Since a photosensitivity reaction is occasionally associated with Griso Ultra therapy, patients should be warned to avoid exposure to intense natural or artificial sunlight. Lupus erythematosus or lupus-like syndromes have been reported in patients receiving Griso Ultra. Griso Ultra decreases the activity of warfarin-type anticoagulants so that patients receiving these drugs concomitantly may require dosage adjustment of the anticoagulant during and after Griso Ultra therapy. Barbiturates usually depress Griso Ultra activity and concomitant administration may require a dosage adjustment of the antifungal agent.

Use During Pregnancy and Lactation

Griso Ultra 125 mg (Griseofulvin [Ultra Microsize]) should not be prescribed to pregnant patients. If the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.

Therapeutic Class

Other Antifungal preparations

Storage Conditions of It

Keep out of reach of children. Store in a dry place, below 25°C temperature and protected from light. Pack Images: Griso Ultra 125 mg Tablet Thanks for using MedEx! How would you rate your experience so far?