Glycovent 25 mcg/ml

Glycovent 25 mcg/ml | INDICATIONS AND USES

Glycopyrrolate respirator solution is indicated for the long-term maintenance treatment for patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.

Glycovent 25 mcg/ml | PHARMACOLOGY

Glycopyrrolate is a long-acting muscarinic antagonist which has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of M3 receptor at the smooth muscle leading to bronchodilation.

Glycovent 25 mcg/ml | DOSAGE & ADMINISTRATION

The Glycopyrronium nebulizer solution is intended only for inhalation with high-efficiency mesh nebulizer and should not be taken orally or administered parenterally. The recommended dose of Glycopyrrolate is the inhalation of the contents of one ampoule twice-daily with high-efficiency mesh nebulizer. Glycopyrrolate should be administered at the same time of the day, (1 ampoule in the morning and 1 ampoule in the evening), every day. More frequent administration or a greater number of inhalations (more than 1 ampoule twice daily) of Glycopyrronium Bromide inhalation solution is not recommended.Store the ampoule in the blister foil, and only remove immediately before use. No dosage adjustment is required for geriatric patients, patients with hepatic impairment, or patients with mild to moderate renal impairment.How to use:

Open the packet and remove the blister. Carefully separate an ampoule from the blister.
Twist of the top. Always hold the ampoule upright.
Squeeze the desired amount of the Nebuliser Solution into the Nebuliser chamber.
If dilution is needed follow the doctors instruction.

Glycovent 25 mcg/ml | DRUG INTERACTIONS

Sympathomimetics and Steroids: In clinical studies, concurrent administration of glycopyrrolate and other drugs commonly used in the treatment of COPD including sympathomimetics (long and short-acting beta2 agonists), anticholinergics (short-acting anti-muscarinic antagonists), oral and inhaled steroids showed no increases in adverse drug reactions.Anticholinergics: There is a potential for an additive interaction with concomitantly used anticholinergic medications. Therefore, avoid unnecessary co-administration of glycopyrrolate with other anticholinergic containing drugs as this may lead to an increase in anticholinergic effects.

Glycovent 25 mcg/ml | SIDE EFFECTS

The following adverse reactions are found:

shortness of breath,
urinary tract infection,
wheezing,
upper respiratory tract infection,
runny nose,
fatigue.

Glycovent 25 mcg/ml | USE DURING PREGNANCY AND LACTATION

There are no adequate and well-controlled studies in pregnant women. Glycopyrrolate should only be used during pregnancy if the expected benefit to the patient outweighs the potential risk to the fetus. Glycopyrrolate is not indicated for use in children.

Glycovent 25 mcg/ml | PRECAUTIONS & WARNINGS

Do not initiate in acutely deteriorating COPD or to treat acute symptoms-

If paradoxical bronchospasm occurs, discontinue Glycopyrronium nebulizer solution immediately and institute alternative therapy
Worsening of narrow-angle glaucoma may occur. Use with caution in patients with narrow-angle glaucoma & instruct patients to contact a physician immediately if symptoms occur
Worsening of urinary retention may occur. Use with caution in patients with prostatic hyperplasia or bladder neck obstruction and instruct patients to consult a physician immediately if symptoms occur.
As the product contains no preservative, a fresh ampoule should be used for each dose and ampoule should be opened immediately before administration. Do not store above 25°C.

Glycovent 25 mcg/ml | THERAPEUTIC CLASS

Bronchodilator

Glycovent 25 mcg/ml | STORAGE CONDITIONS

Keep in a dry place and store below 30°C. Protect from light and keep out of the reach of children.