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DBID
Registration ID: 176322642
Trade License: TRAD/DNCC/040904/2023
Copyright © All Samadhan - Operated by M/S. Genius Experts | All Rights Reserved
DBID
Registration ID: 176322642
Trade License: TRAD/DNCC/040904/2023
Globe Pharmaceuticals Ltd. · Ophthalmic Solution
/ 5 ml drop
The information provided on All Samadhan is intended for general informational purposes only and is prepared based on our best practices. It is not a substitute for professional medical advice, diagnosis, or treatment. While we strive to keep the information accurate and up to date, we do not guarantee its completeness or accuracy. The absence of specific information or warnings about any medicine or service should not be considered as an assurance or endorsement by All Samadhan. All Samadhan shall not be held responsible for any consequences arising from the use of this information. We strongly recommend consulting a qualified healthcare professional or physician for any medical concerns, questions, or clarifications.
Timolol Maleate Ophthalmic Solution is indicated in-
Ocular hypertension
Chronic open-angle glaucoma
Aphakic and secondary glaucoma
Timolol Maleate is a beta-adrenoceptor blocking agent; Timolol has the action of reducing elevated intraocular pressure, whether or not accompanied by glaucoma. The action of Timolol is usually rapid, occurring approximately 20 minutes following ocular instillation and maximum effect occurs in one to two hours. Significant lowering of intraocular pressure has been maintained for periods as long as 24 hours with Timolol 0.25% or 0.50%. Unlike miotics, Timolol has practically no effect on pupil size. No change in visual acuity has observed.
The usual starting dose is one drop of 0.25% Timolol in the affected eye twice a day.If the clinical response is not adequate, the dosage may be changed to one drop of 0.50% solution in the affected eye twice a day. Since in some patients the pressure lowering response to Timolol may require a few weeks to stabilize, evaluation should include a determination of intraocular pressure after approximately 4 weeks of treatment with Timolol.If the intraocular pressure is maintained at satisfactory level, the dosage schedule may be changed to one drop once a day. Use in children: Clinical studies in children have not been conducted. Timolol Maleate is not recommended in premature baby and Newborn
Beta-blocking agents may lead to hypotension and/or severe bradycardia, and when combined with Timolol Maleate may produce additive effects. Ophthalmic supervision is required in case of concomitant therapy with eye drops containing adrenaline (mydriasis may occur).
Timolol Maleate ophthalmic solution is generally well-tolerated. In clinical studies of Timolol Maleate the adverse reactions reported were mainly:Ocular: symptoms of ocular irritation including conjunctivitis, blepharitis, keratitis, visual disturbances including refractive changes (due to withdrawal of miotics therapy in some cases].Cardiovascular: bradycardia, arrythmia, hypotension, syncope, heart block, cerebro-vascular accident, cerebral ischemia, congestive heart failure, palpitation, cardiac arrest.Respiratory: bronchospasm, respiratory failure and dyspnea.Systemic: headache, nausea, dizziness, depression, fatigue.
Timolol Maleate has not yet been studied in human pregnancy.
Patients with inadequate cardiac function, DM, myasthenia gravis, cerebrovascular insufficiency, history of atopy. Avoid abrupt withdrawal as it may exacerbate angina symptoms or precipitate MI in patients with coronary artery disease, or precipitate thyroid crisis in patients with thyrotoxicosis. Patients undergoing major surgery. May mask signs of hyperthyroidism and hypoglycaemia. Ophth soln should not be used as monotherapy for angle-closure glaucoma. Renal and hepatic impairment. Pregnancy and lactation.
Drugs for miotics and glaucoma
The drug is to be used within 30 days after first opening. Store at 15°-25°C. Protect from light. The bottle is to be closed strongly immediately after use. keep out of reach of children.