Giran 16 mg is a Product of the Generic Candesartan Cilexetil

Giran 16 mg belongs to the generic category of Candesartan Cilexetil. This medicine should be used according to a doctor's advice. We have provided detailed information about the uses, dosage, effectiveness, side effects, precautions, drug interactions, storage conditions, and other important details of Giran 16 mg. Our goal is to present essential medicine information in one place for patients, caregivers, and healthcare professionals. To better understand Candesartan Cilexetil and ensure the safe use of this medicine, please read the information below carefully and consult a healthcare professional when necessary.

Description of Giran 16 mg

Giran 16 mg may be available as a prescription or over-the-counter medicine, depending on local regulations and medical recommendations. It is used for the treatment and management of specific conditions or symptoms. The way this medicine is used may vary depending on the patient's condition and the advice of a healthcare provider. Detailed information about the approved uses, therapeutic applications, and other relevant details of Giran 16 mg is provided below to help users gain a clear understanding of this medicine.

Giran 16 mg | INDICATIONS AND USES

Candesartan Cilexetil is indicated for hypertension, heart failure with impaired left ventricular systolic function.

Giran 16 mg | PHARMACOLOGY

Candesartan Cilexetil is an ester prodrug that is hydrolysed in the body to the active form Candesartan during absorption from the gastro-intestinal tract. Candesartan is angiotensin II receptor (type AT1) antagonist. Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues (eg, vascular smooth muscle, adrenal gland).

Giran 16 mg | DOSAGE & ADMINISTRATION

Hypertention: initially 8 mg (hepatic impairment 2 mg, renal impairment or intravascular volume depletion 4 mg) once daily, increased if necessary at intervals of 4 weeks to max 32 mg once daily; usual maintenance dose 8 mg once daily.Heart failure: initially 4 mg once daily, increased at intervals of at least 2 weeks to target dose of 32 mg once daily or to max tolerated dose.

Giran 16 mg | DRUG INTERACTIONS

No significant drug interactions have been reported in studies of Candesartan Cilexetil given with other drugs such as glyburide, nifedipine, digoxin, warfarin, hydrochlorothiazide and oral contraceptives in healthy volunteers. Because candesartan is not metabolised by the cytochrome P-450 system and has no effects on P-450 enzymes, interactions with drugs that inhibit, or are metabolised by, those enzymes could not be expected.

Giran 16 mg | SIDE EFFECTS

Side-effects are usually mild. Symptomatic hypotension including dizziness may occur, particularly in patients with intravascular volume depletion (e.g. those taking high dose diuretics). Hyperkalemia occurs occassionally; angioedema has also been reported with some angiotension II receptor antagonist. Also vertigo, headache; rarely hepatitis, blood disorders, hyponatraemia, back pain, arthralgia, myalgia, rash, urticaria, pruritous.

Giran 16 mg | USE DURING PREGNANCY AND LACTATION

When pregnancy is detected, Candesartan Cilexetil should be discontinued as soon as possible. It should be used in lactation.

Giran 16 mg | PRECAUTIONS & WARNINGS

Candesartan should be used with caution in renal artery stenosis, aortic or mitral valve stenosis and in obstructive hypertropic cardiomyopathy. Monitoring of plasma-potassium concentration is advised, particularly in the elderly and in patients with renal impairment; lower initial doses may be appropriate in these patients.

Giran 16 mg | USE IN SPECIAL POPULATIONS

Use in pediatric: Safety and effectiveness in pediatric patients have not been established.

Giran 16 mg | THERAPEUTIC CLASS

Angiotensin-ll receptor blocker

Giran 16 mg | STORAGE CONDITIONS

Store in a cool & dry place. Protect from light and moisture