G-Mag Sulph 4 gm/100 ml

INDICATIONS

Magnesium Sulfate injection is indicated mainly for the treatment of hypomagnesaemia and magnesium deficiency states. Irregular heart beats, some time it may be used as a laxative. Magnesium Sulfate injection is used in the treatment of magnesium deficiency. Magnesium Sulfate has anticonvulsant properties ... Read moreMagnesium Sulfate injection is indicated mainly for the treatment of hypomagnesaemia and magnesium deficiency states. Irregular heart beats, some time it may be used as a laxative. Magnesium Sulfate injection is used in the treatment of magnesium deficiency. Magnesium Sulfate has anticonvulsant properties when administered parentally, it may be used to prevent or control of Seizures associated with acute uremia, hypothyroidism and eclampsia. It is also used in bronchial asthma & cardiovascular disorder.

PHARMACOLOGY

Magnesium is the second most plentiful cation of intracellular fluids. It is essential for the activity of many enzyme systems and plays an important role with regard to neurochemical transmission and muscular excitability. Deficits are accompanied by a variety of structural and functional disturbances.

DOSAGE & ADMINISTRATION

Adult dose-

Intramuscular: For severe hypomagnesemia, 1 to 5 g (2 to 10 mL of 50% solution) daily in divided doses; administration is repeated daily until serum levels have returned to normal. If the deficiency is not severe, 1 g (2 ml of 50% solution) can be given once or twice daily. Serum magnesium levels should serve as a guide to continued dosage.
Intravenous: 1 to 4 g magnesium sulfate injection may be given intravenously in 10% to 20% solution, but only with great caution; the rate should not exceed 1.5 mL of 10% solution or equivalent per minute until relaxation is obtained.
Usual Dose Range: 1 to 40 g daily.
Electrolyte Replenisher: Intramuscular 1 to 2 g in 50% solution four times a day until serum magnesium is within normal limits.

Usual Pediatric Dose-

Intramuscular: 20 to 40 mg per kg of body weight in a 20% solution repeated as necessary.
For Eclampsia: Initially, 1 to 2 g in 25% or 50% solution is given intramuscularly. Subsequently, 1 g is given every 30 minutes until relief is obtained. The blood pressure should be monitored after each injection.

Use in Children & Adolescents: Magnesium Sulfate seems to be beneficial in the treatment of moderate to severe asthma in children as adjuvant therapy.

INTERACTION

With medicine: Magnesium Sulfate may cause a reduction in blood pressure when taken together with Calcium channel blockers such as nifedipine. There may be an increase in the effects of neuromuscular blocking agents when given together with Magnesium Sulfate. When Magnesium Sulfate is given together with the following medicines there may be a risk of respiratory depression on high-dose barbiturates, opioids and aminoglycosides antibiotics.With food & others: There is no interaction of Magnesium Sulfate with food & others.

SIDE EFFECTS

Common: Excessive administration of magnesium leads to the development of hypermagnesaemia. Symptoms of hypermagnesaemia may include nausea, vomiting, flushing of skin, thirst, hypotension due to peripheral vasodilatation, drowsiness, confusion, muscle weakness etc.Rare: Diarrhea or skin irritation after soaking may occur.

PREGNANCY & LACTATION

Magnesium Sulfate crosses the placenta. So, as with any other drugs, caution is required when the drug is administered to pregnant women. It is not known whether the drug is excreted in human milk. As it happens with many other drugs, cautions should be taken when it is administered to a nursing mother.

PRECAUTIONS & WARNINGS

Magnesium salts should be administered with caution to patients with impaired renal function or those receiving digitalis glycosides. Parenteral administration of magnesium salts may enhance the effect of neuromuscular blocking agents or of central nervous system depressants. Monitor blood pressure, respiratory rate, urinary output and for signs of over dosage like loss of patellar reflex, weakness, nausea, sensation of warmth, flushing of skin, drowsiness, double, vision and slurred speech.

THERAPEUTIC CLASS

Specific mineral preparations

STORAGE CONDITIONS

Store in a cool & dry place, keep away from light & children.