G-Aspirin 300 mg

INDICATIONS

Aspirin is indicated in the following indications-

Prophylaxis against arterial occlusive events: Myocardial infarction, myocardial re-infarction, after bypass surgery, acute ischaemic stroke/TIA.
Mild to moderate pain: Headache, muscle pain, dysmenorrhoea and toothache etc.
Chronic disease accompanied by pain and inflammation: Osteoarthritis.
Antipyretic: Cold fever and influenzae.

PHARMACOLOGY

By decreasing platelet aggregation, Aspirin inhibits thrombus formation on the arterial side of the circulation, where thrombi are formed by platelet aggregation and anticoagulants have little effect. Aspirin is the analgesic of choice for headache, transient musculoskeletal pain and dysmenorrhoea. It has anti-inflammatory and antipyretic properties, which may be useful. Enteric-coated Aspirin reduces intestinal disturbance and gastrointestinal ulceration due to aspirin.

DOSAGE & ADMINISTRATION

Pain, inflammatory diseases and as antipyretic: Aspirin 300 mg 1-3 tablets 6 hourly with a maximum daily dose of 4 gm.Suspected acute coronary syndrome: 150 mg-300 mg immediately unless there are clear contraindications.After myocardial infarction: Aspirin 150 mg daily for 1 month. Long-term use of aspirin in a dose of 75 mg daily is recommended thereafter.Acute ischaemic stroke/Transient ischaemic stroke (TIA): The starting dose is 150 mg-300 mg daily and Aspirin 75 mg daily thereafter.Following bypass surgery: 75 mg-300 mg daily starting 6 hours post-procedure.

INTERACTION

Salicylates may enhance the effect of anticoagulants, oral hypoglycaemic agents, phenytoin and sodium valporate. They inhibit the uricosuric effect of probenecid and may increase the toxicity of sulphonamides. They may also precipitate bronchospasm or induce attacks of asthma in susceptible subjects.

SIDE EFFECTS

Side effects for the usual dosage of Aspirin are mild including nausea, dyspepsia, gastrointestinal ulceration and bronchospasm etc.

PREGNANCY & LACTATION

It is especially important not to use aspirin during the last 3 months of pregnancy unless specifically directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Aspirin penetrates into breast milk. So, it should be administered with caution to lactating mothers.

PRECAUTIONS & WARNINGS

It should be administered cautiously in asthma, uncontrolled blood pressure, and pregnant women. It should be administered with caution to patients with a nasal polyp and nasal allergy.

THERAPEUTIC CLASS

Anti-platelet drugs

STORAGE CONDITIONS

Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.