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DBID
Registration ID: 176322642
Trade License: TRAD/DNCC/040904/2023
Copyright © All Samadhan - Operated by M/S. Genius Experts | All Rights Reserved
DBID
Registration ID: 176322642
Trade License: TRAD/DNCC/040904/2023
Orion Pharma Ltd. · Tablet
/ Piece
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Faropenem Tablets are indicated in the treatment of the following infections:
Lower respiratory tract infections: acute bronchitis, pneumonia, pulmonary suppuration.
Ear, nose, and throat (ENT) infections: otitis externa, tympanitis, sinusitis. ... Read moreFaropenem Tablets are indicated in the treatment of the following infections:
Lower respiratory tract infections: acute bronchitis, pneumonia, pulmonary suppuration.
Ear, nose, and throat (ENT) infections: otitis externa, tympanitis, sinusitis.
Genito-urinary infections: pyelonephritis, cystitis, prostatitis, seminal gland inflammation.
Upper respiratory tract infections: pharyngitis, tonsillitis.
Skin and skin structure infections: pustular acne, folliculitis, contagious impetigo, erysipelas, lymphangitis, suppurative nail inflammation, subcutaneous abscess, hidradenitis (sweat gland inflammation), infective sebaceous cyst, chronic pyoderma, secondary infection of external wounds or surgical wounds.
Gynecological infections: adnexitis, bartholin gland inflammation.
Faropenem is a penem class of antimicrobial and has bactericidal activity against a variety of gm-ve, gm+ve and anaerobic bacteria. Faropenem is bactericidal, with a strong affinity for the high molecular penicillin binding proteins (PBPs) of the cell wall, which is essential for the multiplication of bacilli; it, thus, acts by inhibiting the cell wall synthesis. Faropenem shows broad antibacterial activity against both aerobic and anaerobic Gram-positive and Gram-negative bacteria. Faropenem is highly stable against various beta lactamases and binds preferentially to the PBPs, 2 and 1A, of Escherichia coli (E. coli).
Upper respiratory tract infections: 150 mg t.i.d., can be increased to 200 mg t.i.d.ENT infections: 200 mg t.i.d., can be increased to 300 mg t.i.d.Lower respiratory tract infections: 200 mg t.i.d., can be increased to 300 mg t.i.d.Skin and skin structure infections: 150 mg t.i.d., can be increased to 200 mg t.i.d.Genito-urinary infections: 200 mg t.i.d., can be increased to 300 mg t.i.d.Gynecological infections: 150 mg t.i.d., can be increased to 200 mg t.i.d.
Imipenem and Cilastatin sodium combination: It has been reported that in animal studies (rat), the concentration of faropenem in the blood increases. It is due to the obstruction of metabolic fermentation by cilastatin.Furosemide: It has been reported in animal studies (dog), that the kidney toxicity of faropenem increases.Sodium valproate: It has been reported that due to joint usage with carbapenem drugs (meropenem, panipenem and imipenem-cilastatin sodium) the concentration of valproic acid in the blood reduces, and there is a recurrence of epileptic fits.
Common side effects of this drug are Headache, Nausea, Vomiting, Stomach pain and Diarrhea.
Safety regarding therapy during pregnancy has not been established. In pregnant women or expectant mothers, the medicine should be given only if the benefit of the treatment is greater than the risks involved. Faropenem is excreted in human milk. Therefore, Faropenem should be given to nursing mothers only if the benefits outweigh the risks.
Faropenem should be administered with caution in the following:
Patients with a past history of hypersensitivity to penicillin, cephem or carbapenem drugs.
Patients with a family history of atopy.
Patients with renal impairment. The dosage should be reduced or the interval between doses should be increased.
Geriatric patients.
Patients with poor oral intake or poor general state (since there are cases that show symptoms of vitamin K deficiency, proper monitoring should be done).
Renal Impairment: In patients with renal impairment, it was found that the plasma concentrations of the drug are increased, and the half-life is extended.Geriatric Use: The half-life of Faropenem is prolonged in the elderly and this may be due to a decline in kidney functions, which results in high plasma concentrations. Therefore, in the elderly, start with a dose of 150 mg and monitor the patient for any undesirable effects. If diarrhea and loose bowel movements appear, stop the medicine, monitor correctly, and take appropriate measures. There is a tendency of hemorrhage due to vitamin K deficiency in the elderly.
Store Faropenem at room temperature between 20°C to 25°C in its original package. Safely throw away any Faropenem that is out of date or no longer needed. Keep Faropenem and all medicines out of the reach of children. Protect from moisture.