What Is Fantagesic 100 mcg/2 ml Indications and Uses?

Fantagesic 100 mcg/2 ml (Fentanyl Citrate) is indicated for the management of breakthrough pain in patients with cancer who are already receiving and who are tolerant to opioid therapy for their underlying persistent cancer pain. Patients considered opioid tolerant are those who are taking at least 60 mg of oral morphine/day, at least 25 mcg of transdermal Fantagesic/hour, at least 30 mg of oxycodone daily, at least 8 mg of oral hydromorphone daily or an equianalgesic dose of another opioid for a week or longer.

Pharmacology (Source, Chemical and Physical Composition) Of Fantagesic 100 mcg/2 ml

Fantagesic 100 mcg/2 ml (Fentanyl Citrate) is an opioid analgesic. Fentanyl interacts predominately with the opioid mu-receptor but also binds to kappa and delta-type opioid receptors. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, Fentanyl exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Fentanyl may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Fentanyl depresses the respiratory centers, depresses the cough reflex, and constricts the pupils.

Drug Interactions of Fantagesic 100 mcg/2 ml

Co-administration of different antifungals, macrolide antibiotics, CNS depressant drugs like ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, and nefazadone may enhance or prolong the effects of Fantagesic 100 mcg/2 ml (Fentanyl Citrate). The concomitant use of amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, and verapamil with Fantagesic may also result in an increase in Fantagesic plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression.

Side Effects of Fantagesic 100 mcg/2 ml

As with other narcotic analgesics, the most common serious adverse reactions reported to occur with Fantagesic 100 mcg/2 ml (Fentanyl Citrate) are respiratory depression, apnoea, muscular rigidity, myoclonic movements, and bradycardia. Respiratory depression is more likely to occur with intravenous administration if a dose is given too rapidly and it rarely occurs with intramuscular administration.

Precautions And Warnings for Fantagesic 100 mcg/2 ml

Opioid analgesics impair the mental and/or physical ability required for the performance of potentially dangerous tasks (e.g. driving a car or operating machinery). Patients taking Fantagesic 100 mcg/2 ml (Fentanyl Citrate) should be warned of these dangers and should be counseled accordingly. The use of concomitant CNS active drugs requires special patient care and observation. Chronic pulmonary disease : Fantagesic should be titrated with caution in patients with chronic obstructive pulmonary disease or pre-existing medical conditions predisposing them to respiratory depression. Head injuries and increased intracranial pressure : Opioids may obscure the clinical course of a patient with a head injury and should be used only if clinically warranted. Cardiac disease : Intravenous Fantagesic may produce bradycardia. Therefore, Fantagesic should be used with caution in patients with bradyarrhythmias. Hepatic or renal disease : Fantagesic should be used with caution because of the hepatic metabolism and renal excretion of Fantagesic.

Use During Pregnancy and Lactation

Pregnancy category C. There are no adequate and well-controlled studies in pregnant women. Fantagesic 100 mcg/2 ml (Fentanyl Citrate) should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fentanyl is excreted in human milk; therefore Fentanyl should not be used in nursing women because of the possibility of sedation and/or respiratory depression in their infants.

Therapeutic Class

Opioid analgesics

Storage Conditions of It

Store between 20-25°C. Protect from light. Pack Images: Fantagesic 100 mcg Injection Thanks for using MedEx! How would you rate your experience so far?