Evatone 1 mg+100 mg

Evatone 1 mg+100 mg | INDICATIONS AND USES

This combination capsule is indicated for use during continuous combined Hormone Replacement Therapy (HRT) for estrogen deficiency symptoms in postmenopausal women with an intact uterus and with at least 12 months since last menses.

Evatone 1 mg+100 mg | PHARMACOLOGY

Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. The production of estradiol by the ovaries is under the control of pituitary gonadotropins, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). Circulating estrogens modulate LH and FSH, through a negative feedback mechanism. In menopausal women, the depletion of ovarian follicles leads to lower plasma estradiol and elevated plasma FSH and LH. The addition of progesterone opposes the development of endometrial hyperplasia

Evatone 1 mg+100 mg | DOSAGE & ADMINISTRATION

Adult: Take a single capsule orally each evening with food.Pediatrics: This capsule has not been studied in this patient population and is not recommended for use.Geriatrics: This capsule has not been studied in this patient population and is not recommended for use.Hepatic Insufficiency: This capsule is contraindicated in women with liver dysfunction or disease as long as liver function tests have failed to return to normal.Renal Insufficiency: This capsule is to be used with caution in women with renal dysfunction.

Evatone 1 mg+100 mg | DRUG INTERACTIONS

With Medicine: No drug-drug interaction studies have been conducted with Dizuva.With Food and Others: The exposure of Dizuva can be affected by food intake. Inhibitors of CYP 3A4 such as grapefruit juice may increase plasma concentrations of estrogens and may result in side effects

Evatone 1 mg+100 mg | SIDE EFFECTS

Common: Alopecia, nausea, abdominal pain, headache, fatigue, flatulence, dizziness, vaginal hemorrhage, vaginal discharge, uterine spasm, pelvic pain and breast pain.Rare: Ear swelling, vertigo, hirsutism, dry eye, vision blurred, visual impairment, vitreous floaters, cholelithiasis, unstable angina.

Evatone 1 mg+100 mg | USE DURING PREGNANCY AND LACTATION

This is not recommended during pregnancy, labor or delivery and in mothers who are breast feeding.

Evatone 1 mg+100 mg | PRECAUTIONS & WARNINGS

Women using HRT sometimes experience increased blood pressure. Blood pressure should be monitored with HRT use. Elevation of blood pressure in previously normotensive or hypertensive patients should be investigated and HRT may have to be discontinued. Estrogens with or without progestins may cause fluid retention. Therefore, particular caution is indicated in cardiac or renal dysfunction or asthma.Patients who develop visual disturbances, classical migraine, transient aphasia, paralysis or loss of consciousness should discontinue medication.

Evatone 1 mg+100 mg | THERAPEUTIC CLASS

Drugs for menopausal symptoms: Hormone replacement therapy, Female Sex hormones

Evatone 1 mg+100 mg | STORAGE CONDITIONS

Do not store above 25°C. Protect from light. Keep out of the reach of children.