Etogesic SR Tablet (Sustained Release) SR Tablet 600 mg is a Product of the Generic Etodolac

What Is Etogesic SR Tablet (Sustained Release) SR Tablet 600 mg Indications and Uses?

Etogesic SR is indicated- For acute and long-term use in the management of signs and symptoms: Osteoarthritis, Rheumatoid arthritis For the management of acute pain Acute gout

Pharmacology (Source, Chemical and Physical Composition) Of Etogesic SR Tablet (Sustained Release) SR Tablet 600 mg

Similar to other NSAIDs, the anti-inflammatory effects of Etogesic SR Tablet (Sustained Release) SR Tablet 600 mg (Etodolac) result from inhibition of the enzyme cycooxygenase (COX). This decreases the synthesis of peripheral prostaglandins involved in mediating inflammation. Etodolac binds to the upper portion of the COX enzyme active site and prevents its substrate, arachidonic acid, from entering the active site. Etodolac was previously thought to be a non-selective COX inhibitor, but it is now known to be 5-50 times more selective for COX-2 than COX-1. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.

Dosage And Administration of Etogesic SR Tablet (Sustained Release) SR Tablet 600 mg

Adults and over 18 years: Etogesic SR Tablet (Sustained Release) SR Tablet 600 mg (Etodolac) 300 mg capsule: 600 mg daily in 1-2 divided doses Etodolac 600 mg ER tablet: Once daily Pediatric: Safety and effectiveness in pediatric patients below the age of 18 years have not been established.

Drug Interactions of Etogesic SR Tablet (Sustained Release) SR Tablet 600 mg

Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors. When Etogesic SR is administered with Aspirin, its protein binding is reduced, although the clearance of free Etogesic SR is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of Etogesic SR and Aspirin is not generally recommended because of the potential of increased adverse effects.

Side Effects of Etogesic SR Tablet (Sustained Release) SR Tablet 600 mg

The common side effects of Etogesic SR involve the gastrointestinal system. It can cause abdominal pain, constipation, diarrhea, dyspepsia, flatulence, heartburn, nausea, Gl ulcers, vomiting. Other events including abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritis, rashes, tinnitus etc.

Precautions And Warnings for Etogesic SR Tablet (Sustained Release) SR Tablet 600 mg

Etogesic SR should be given with caution in patients with severe hepatic reactions, pre existing asthma, fluid retention, hypertension or heart failure. If clinical sings and symptoms consistent with liver disease develop, or if systemic manifestations occur (e.g. eosinophilia, rash etc.), it should be discontinued.

Use During Pregnancy and Lactation

There are no adequate and well-controlled studies in pregnant women. It should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Etogesic SR Tablet (Sustained Release) SR Tablet 600 mg (Etodolac) is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug taking into account the importance of the drug to the mother.

Therapeutic Class

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions of It

Do not store above 30°C. Keep away from light and out of the reach of children. Thanks for using MedEx! How would you rate your experience so far?