Esoral MUPS MUPS Tablet MUPS Table 40 mg is a Product of the Generic Esomeprazole

What Is Esoral MUPS MUPS Tablet MUPS Table 40 mg Indications and Uses?

Adults (from the age of 18 years)- Gastroesophageal reflux disease (GERD): Non-erosive reflux disease (NERD) (i.e. heartburn and regurgitation), Maintenance treatment of NERD (i.e. heartburn and regurgitation), Reflux esophagitis or erosive esophagitis, ... Read more Adults (from the age of 18 years)- Gastroesophageal reflux disease (GERD): Non-erosive reflux disease (NERD) (i.e. heartburn and regurgitation), Maintenance treatment of NERD (i.e. heartburn and regurgitation), Reflux esophagitis or erosive esophagitis, Maintenance treatment of patients with reflux esophagitis Healing of NSAID associated gastric ulcers Reduction of risk of NSAID associated gastric ulcers Zollinger-Ellison Syndrome H. pylori eradication Pediatrics (12-17 years of age)- Gastroesophageal reflux disease (GERD) Non-erosive reflux disease (NERD) (i.e. heartburn and regurgitation) Reflux esophagitis or erosive esophagitis.

Pharmacology (Source, Chemical and Physical Composition) Of Esoral MUPS MUPS Tablet MUPS Table 40 mg

The proton pump inhibitor Esoral MUPS MUPS Tablet MUPS Table 40 mg (Esomeprazole) inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system (the proton pump) of the gastric parietal cell. Proton pump inhibitors are effective for short-term treatment of gastric and duodenal ulcers. Esomeprazole is also used in the prevention and treatment of NSAID associated gastric ulcers.

Drug Interactions of Esoral MUPS MUPS Tablet MUPS Table 40 mg

Esoral MUPS is extensively metabolized in the liver by CYP2C19 and CYP3A4. In vitro and in vivo studies have shown that Esoral MUPS is not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4. No clinically relevant interactions with drugs metabolized by these CYP enzymes would be expected. Drug interaction studies have shown that Esoral MUPS does not have any clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin. Esoral MUPS may potentially interfere with CYP2C19, the major Esoral MUPS metabolizing enzyme. Co-administration of Esoral MUPS 30 mg anddiazepam, a CYP2C19 substrate has resulted in a 45% decrease in clearance of diazepam. Increased plasma levels of diazepam have been observed 12 hours after dosing and onwards. Esoral MUPS inhibits gastric acid secretion. Therefore, Esoral MUPS may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts and digoxin). Co-administration of oral contraceptives, diazepam, phenytoin, or quinidine do not seem to change the pharmacokinetic profile of Esoral MUPS. Combination Therapy with Clarithromycin: Co-administration of Esoral MUPS, clarithromycin, and amoxicillin has resulted in increases in the plasma levels of Esoral MUPS and 14-hydroxyclarithromycin.

Side Effects of Esoral MUPS MUPS Tablet MUPS Table 40 mg

The most common side effects of Esoral MUPS are nausea, vomiting, abdominal pain, flatulence, diarrhea, constipation and headache. Less frequent side effects include dry mouth, peripheral edema, dizziness, sleep disturbances, fatigue, paraesthesia, arthralgia, myalgia, rash and pruritus. Other side effects reported rarely or very rarely include taste disturbance, stomatitis, hepatitis, jaundice, hypersensitivity reactions (including anaphylaxis, bronchospasm), fever, depression, hallucinations, confusion, gynaecomastia, interstitial nephritis, hyponatraemia, blood disorders (including leucopenia, leukocytosis, pancytopenia, thrombocytopenia), visual disturbances, sweating, photosensitivity, alopecia, Stevens-Johnson Syndrome and toxic epidermal necrolysis.

Precautions And Warnings for Esoral MUPS MUPS Tablet MUPS Table 40 mg

Esoral MUPS should be used carefully if the patient has severe liver dysfunction and severe renal impairment. Taking a proton pump inhibitor like Esoral MUPS may slightly increase the risk of hip, wrist and spine fracture, particularly when it is taken over a period of more than one year.

Use During Pregnancy and Lactation

Pregnancy : For Esoral MUPS MUPS Tablet MUPS Table 40 mg (Esomeprazole), limited clinical data on exposed pregnancies are available. Esomeprazole should only be given to pregnant women if its use is considered essential. Lactation : It is not known whether esomeprazole is excreted in breast milk. Therefore esomeprazole should not be used during breast-feeding.

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions of It

Store in a cool & dry place below 25ºC, protect from light. Keep out of reach of children.