Epicure IV 50 mg/5 ml is a Product of the Generic Brivaracetam

What Is Epicure IV 50 mg/5 ml Indications and Uses?

Epicure is indicated for the treatment of partial onset seizures in patients 1 month of age and older.

Pharmacology (Source, Chemical and Physical Composition) Of Epicure IV 50 mg/5 ml

This is a preparation of Epicure IV 50 mg/5 ml (Brivaracetam) which is an anticonvulsant. The precise mechanism by which Brivaracetam exerts its anticonvulsant activity is not known. Brivaracetam displays a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain which may contribute to the anticonvulsant effect.

Drug Interactions of Epicure IV 50 mg/5 ml

Co-administration with rifampin decreases Epicure plasma concentrations likely because of CYP2C19 induction. Prescribers should increase the Epicure dose by up to 100% (i.e., double the dose) in patients while receiving concomitant treatment with rifampin. Co-administration with carbamazepine may increase exposure to carbamazepine-epoxide, the active metabolite of carbamazepine. If tolerability issues arise when co-administered, carbamazepine dose reduction should be considered. Because Epicure can increase plasma concentrations of phenytoin, phenytoin levels should be monitored in patients when concomitant Epicure is added to or discontinued from ongoing phenytoin therapy. Epicure provided no added therapeutic benefit to levetiracetam when the two drugs were co-administered.

Side Effects of Epicure IV 50 mg/5 ml

The most common side effects are nausea/vomiting, constipation, somnolence and sedation, dizziness, fatigue, cerebellar coordination and balance disturbances and irritability.

Precautions And Warnings for Epicure IV 50 mg/5 ml

Antiepileptic drugs (AEDs), including Epicure, increase the risk of suicidal thoughts or behavior. Patients treated with any AED should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior and/or any unusual changes in mood or behavior. Epicure causes somnolence, fatigue, dizziness and disturbance in coordination. Patients should be monitored for these signs and symptoms and advised not to drive or operate machinery. Epicure causes psychiatric adverse reactions which included both non-psychotic symptoms (irritability, anxiety, nervousness, aggression, belligerence, anger, agitation, restlessness, depression, depressed mood, tearfulness, apathy, mood swings, psychomotor hyperactivity, abnormal behavior and adjustment disorder) and psychotic symptoms (psychotic disorder along with hallucination, paranoia, acute psychosis and psychotic behavior). As with most antiepileptic drugs, Epicure should generally be withdrawn gradually because of the risk of increased seizure frequency and status epilepticus.

Use During Pregnancy and Lactation

Pregnancy : Epicure IV 50 mg/5 ml (Brivaracetam) should not be used during pregnancy unless clinically necessary i.e. (if the benefit to the mother clearly outweighs the potential risk to the fetus). Lactation : No data are available regarding the presence of brivaracetam in human milk, the effects on the breastfed infant or the effects of the drug on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for brivaracetam and any potential adverse effects on the breastfed infant from brivaracetam or from the underlying maternal condition.

Therapeutic Class

Adjunct anti-epileptic drugs

Storage Conditions of It

Store in a cool (below 30°C) and dry place protected from light. Keep away from the reach of children. Pack Image: Epicure 50 mg/5 ml Injection Thanks for using MedEx! How would you rate your experience so far?