OTC

Dizuva 1 mg+100 mg

Ziska Pharmaceuticals Ltd. · Capsule

GenericEstradiol Hemihydrate + Progesterone Micronized

Strength1 mg+100 mg

Total Strip3

Strip Size10

Unit Price

৳ 22

/ Piece

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⚠ Disclaimer

The information provided on All Samadhan is intended for general informational purposes only and is prepared based on our best practices. It is not a substitute for professional medical advice, diagnosis, or treatment. While we strive to keep the information accurate and up to date, we do not guarantee its completeness or accuracy. The absence of specific information or warnings about any medicine or service should not be considered as an assurance or endorsement by All Samadhan. All Samadhan shall not be held responsible for any consequences arising from the use of this information. We strongly recommend consulting a qualified healthcare professional or physician for any medical concerns, questions, or clarifications.

Medicine Description

INDICATIONS

This combination capsule is indicated for use during continuous combined Hormone Replacement Therapy (HRT) for estrogen deficiency symptoms in postmenopausal women with an intact uterus and with at least 12 months since last menses.

PHARMACOLOGY

Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. The production of estradiol by the ovaries is under the control of pituitary gonadotropins, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). Circulating estrogens modulate LH and FSH, through a negative feedback mechanism. In menopausal women, the depletion of ovarian follicles leads to lower plasma estradiol and elevated plasma FSH and LH. The addition of progesterone opposes the development of endometrial hyperplasia

DOSAGE & ADMINISTRATION

Adult: Take a single capsule orally each evening with food.Pediatrics: This capsule has not been studied in this patient population and is not recommended for use.Geriatrics: This capsule has not been studied in this patient population and is not recommended for use.Hepatic Insufficiency: This capsule is contraindicated in women with liver dysfunction or disease as long as liver function tests have failed to return to normal.Renal Insufficiency: This capsule is to be used with caution in women with renal dysfunction.

INTERACTION

With Medicine: No drug-drug interaction studies have been conducted with Dizuva.With Food and Others: The exposure of Dizuva can be affected by food intake. Inhibitors of CYP 3A4 such as grapefruit juice may increase plasma concentrations of estrogens and may result in side effects

SIDE EFFECTS

Common: Alopecia, nausea, abdominal pain, headache, fatigue, flatulence, dizziness, vaginal hemorrhage, vaginal discharge, uterine spasm, pelvic pain and breast pain.Rare: Ear swelling, vertigo, hirsutism, dry eye, vision blurred, visual impairment, vitreous floaters, cholelithiasis, unstable angina.

PREGNANCY & LACTATION

This is not recommended during pregnancy, labor or delivery and in mothers who are breast feeding.

PRECAUTIONS & WARNINGS

Women using HRT sometimes experience increased blood pressure. Blood pressure should be monitored with HRT use. Elevation of blood pressure in previously normotensive or hypertensive patients should be investigated and HRT may have to be discontinued. Estrogens with or without progestins may cause fluid retention. Therefore, particular caution is indicated in cardiac or renal dysfunction or asthma.Patients who develop visual disturbances, classical migraine, transient aphasia, paralysis or loss of consciousness should discontinue medication.