Dezide 50 mg+25 mg is a Product of the Generic Triamterene + Hydrochlorothiazide

What Is Dezide 50 mg+25 mg Indications and Uses?

This preparation is indicated-

for the treatment of hypertension or edema in patients who develop hypokalemia on hydrochlorothiazide alone.
for those patients who require a thiazide diuretic and in whom the development of hypokalemia cannot be risked.
alone or as an adjunct to other antihypertensive drugs, such as betablockers. Since this preparation may enhance the action of these agents, dosage adjustments may be necessary. ... Read moreThis preparation is indicated-

for the treatment of hypertension or edema in patients who develop hypokalemia on hydrochlorothiazide alone.
for those patients who require a thiazide diuretic and in whom the development of hypokalemia cannot be risked.
alone or as an adjunct to other antihypertensive drugs, such as betablockers. Since this preparation may enhance the action of these agents, dosage adjustments may be necessary.

This fixed combination drug is not indicated for the initial therapy of edema or hypertension except in individuals in whom the development of hypokalemia cannot be risked.

Pharmacology (Source, Chemical and Physical Composition) Of Dezide 50 mg+25 mg

Triamterene directly inhibits the exchange of Na for K and hydrogen in the distal renal tubule. Hydrochlorothiazide increases the excretion of Na and Cl ions, and consequently of water, by reducing electrolyte reabsorption from the renal tubules.Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of Hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so co-administration of anangiotensin converting enzyme (ACE) inhibitor tends to reverse the potassium loss associated with these diuretics.

Dosage And Administration of Dezide 50 mg+25 mg

The usual dose is one or two capsules given once daily, with appropriate monitoring of serum potassium and of the clinical effect.

Drug Interactions of Dezide 50 mg+25 mg

May reduce the renal clearance of lithium. May antagonise diuretic effect with NSAIDs, corticosteroids, oestrogens, combined OCs. Enhanced effect with other hypotensive agents, baclofen, tizanidine. May decrease arterial responsiveness to norepinephrine. Increases responsiveness to tubocurarine. Risk of acute renal failure with indometacin. Increased risk of hyperkalaemia with reboxetine, tacrolimus. Increased risk of ototoxicity and nephrotoxicity with platinum compounds (e.g. cisplatin).

Side Effects of Dezide 50 mg+25 mg

Hypersensitivity: Anaphylaxis, rash, urticaria, subacute cutaneous lupus erythematosus-like reactions, photosensitivity.Cardiovascular: Arrhythmia, postural hypotension.Metabolic: Diabetes mellitus, hyperkalemia, hypokalemia, hyponatremia, acidosis, hypercalcemia, hyperglycemia, glycosuria, hyperuricemia, hypochloremia.Gastrointestinal: Jaundice and/or liver enzyme abnormalities, pancreatitis, nausea and vomiting, diarrhea, constipation, abdominal pain.Renal: Acute renal failure (one case of irreversible renal failure has been reported), interstitial nephritis, renal stones composed primarily of triamterene, elevated BUN, and serum creatinine, abnormal urinary sediment.Hematologic: Leukopenia, thrombocytopenia and purpura, megaloblastic anemia.Musculoskeletal: Muscle cramps.Central Nervous System: Weakness, fatigue, dizziness, headache, dry mouth.Miscellaneous: Impotence, sialadenitis.Central Nervous System: Paresthesias, vertigo.Ophthalmic: Xanthopsia, transient blurred vision.Respiratory: Allergic pneumonitis, pulmonary edema, respiratory distress.

Use During Pregnancy and Lactation

The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia. Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Diuretics are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy.

Precautions And Warnings for Dezide 50 mg+25 mg

Diabetes: Caution should be exercised when administering Dyazide to patients with diabetes, since thiazides may cause hyperglycemia, glycosuria, and alter insulin requirements in diabetes. Also, diabetes mellitus may become manifest during thiazide administration. Impaired Hepatic Function: Thiazides should be used with caution in patients with impaired hepatic function. They can precipitate hepatic coma in patients with severe liver disease. Potassium depletion induced by the thiazide may be important in this connection. Administer Dyazide cautiously and be alert for such early signs of impending coma as confusion, drowsiness, and tremor; if mental confusion increases discontinue Dyazide for a few days. Attention must be given to other factors that may precipitate hepatic coma, such as blood in the gastrointestinal tract or preexisting potassium depletion.Hypokalemia: Hypokalemia is uncommon with Dyazide; but, should it develop, corrective measures should be taken such as potassium supplementation or increased intake of potassium-rich foods. Institute such measures cautiously with frequent determinations of serum potassium levels, especially in patients receiving digitalis or with a history of cardiac arrhythmias. If serious hypokalemia (serum potassium less than 3.0 mEq/L) is demonstrated by repeat serum potassium determinations, Dyazide should be discontinued and potassium chloride supplementation initiated. Less serious hypokalemia should be evaluated with regard to other coexisting conditions and treated accordingly.Electrolyte Imbalance: Electrolyte imbalance, often encountered in such conditions as heart failure, renal disease or cirrhosis of the liver, may also be aggravated by diuretics and should be considered during therapy with Dyazide when using high doses for prolonged periods or in patients on a salt-restricted diet. Serum determinations of electrolytes should be performed, and are particularly important if the patient is vomiting excessively or receiving fluids parenterally. Possible fluid and electrolyte imbalance may be indicated by such warning signs as: dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal symptoms.

Therapeutic Class

Combined antihypertensive preparations

Storage Conditions of It

Store at controlled room temperature 20° to 25°C; excursions permitted to 15° to 30°C. Protect from light. Dispense in a tight, light-resistant container.