Dextran 10%+5%

Dextran 10%+5% | INDICATIONS AND USES

This preparation is indicated in thromboembolic disorders, hypovolaemic shock, pulmonary embolism, venous thrombosis.

Dextran 10%+5% | PHARMACOLOGY

Dextrans produce expansion of plasma volume. It also reduces blood viscosity and inhibits sludging or aggregation of red blood cells.Dextrose is a monosaccharide that is used as a source of calories and water for hydration. It helps to reduce loss of body protein and nitrogen. It also promotes glycogen deposition in the liver. When used with insulin, it stimulates the uptake of potassium by cells, especially in muscle tissue, thus lowering serum potassium levels.

Dextran 10%+5% | DOSAGE

Adult: IV Hypovolaemic shock As dextran 40 (10% soln): 10 mL/kg/day for up to 5 days.Thromboembolic disorders:

As dextran 40 (10% soln): Initial: 500 ml on day 1, followed by 500 ml on day 2 and subsequently on alternate days up to 10 days. Prophylaxis of post-op thromboembolic disorders. 500 ml during or at the end of surgery. May repeat dose next day and continue treatment on alternate days for up to 10 days in high-risk patients.

Child: As dextran 40: Up to 5 ml/kg in infants and 10 ml/kg in children.

Dextran 10%+5% | DRUG INTERACTIONS

Dextran:

Enzyme inducers e.g. phenytoin or carbamazepine
enzyme inhibitors e.g. cimetidine.

Dextran 10%+5% | SIDE EFFECTS

Congestive heart failure, Mild hypotension, Tightness of chest, Thrombocytopenia, Anaphylaxis, Injection site infection/phlebitis, Acute renal failure, Acidosis (if NaCI soln used), Pulmonary edema, Wheezing

Dextran 10%+5% | USE DURING PREGNANCY AND LACTATION

Pregnancy Category - CAnimal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Dextran 10%+5% | PRECAUTIONS & WARNINGS

Caution should be taken during pregnency

Dextran 10%+5% | THERAPEUTIC CLASS

Plasma expanders