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Copyright © All Samadhan - Operated by M/S. Genius Experts | All Rights Reserved
DBID
Registration ID: 176322642
Trade License: TRAD/DNCC/040904/2023
Copyright © All Samadhan - Operated by M/S. Genius Experts | All Rights Reserved
DBID
Registration ID: 176322642
Trade License: TRAD/DNCC/040904/2023
Ibn Sina Pharmaceuticals Ltd. · Ophthalmic Solution
/ 5 ml drop
The information provided on All Samadhan is intended for general informational purposes only and is prepared based on our best practices. It is not a substitute for professional medical advice, diagnosis, or treatment. While we strive to keep the information accurate and up to date, we do not guarantee its completeness or accuracy. The absence of specific information or warnings about any medicine or service should not be considered as an assurance or endorsement by All Samadhan. All Samadhan shall not be held responsible for any consequences arising from the use of this information. We strongly recommend consulting a qualified healthcare professional or physician for any medical concerns, questions, or clarifications.
This preparation is indicated for steroid responsive infammatory conditions with involvement of bacteria; such as- Blepharitis, Scleritis, Episcleritis, Iritis, Cyclitis, Iridocyclitis, Choroiditis, Optic neuritis and chronic anterior uveitis. Also useful in disciform and interstitial keratitis, allergic corneal marginal ulcers, corneal injury from chemical radiation or thermal burns.
The antibacterial action of Gatifoxacin results from inhibition of DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division. Through inhibiting this process Gatifoxacin shows bactericidal activity. The action of Dexamethasone is to inhibit the phospholipase A2, the frst step in prostaglandin synthesis. Also, inhibits the chemotactic infltration of neutrophils into the site of infammation. Its anti-infammatory activity is 30 times greater and its overall therapeutic efectiveness 8-10 times greater than that of hydrocortisone. Like other glucocorticoids, it is anti-allergic, anti-exudative and anti-proliferative.
Instill 1-2 drops into the conjunctival sac 3 to 4 times daily.
There may be an interaction between Gatifoxacin and any of the followings: Antacids (containing aluminum, calcium, and magnesium), digoxin, probenecid, vitamins (containing zinc, calcium, magnesium, or iron). Specifc drug interaction studies have not been conducted with Dexamethasone.
Frequently reported reactions related to Gatifoxacin include chemosis, redness, dry eye, itching, swelling of the eyelid & reduced visual acuity. The reactions due to Dexamethasone are elevation of intraocular pressure, delayed wound healing and posterior subcapsular cataract formation.
In Pregnancy: Because there are no adequate and well-controlled studies in pregnant women, the eye drops should be used during pregnancy only if the potential beneft justifes the potential risk to the fetus.In Lactation: Gatifoxacin or Dexamethasone has not been measured in human milk, although it can be presumed to be excreted in human milk following topical administration. Caution should be exercised when the combination is administered to a nursing woman.Pediatric Use: The safety in Pediatric patients has not been established.
If the product is used for 10 days or more, intra ocular pressure should be monitored routinely. Prolonged use of steroid may result in glaucoma or other ocular damage. It may exacerbate severity of viral infections. Use cautiously in patients with history of herpes simplex.
Use in children: Safety and effectiveness in pediatric patients have not been established.
Ophthalmic steroid - antibiotic combined preparations
Store in a cool and dry place away from light. Keep out of reach of children. Do not touch the dropper tip to surfaces since this may contaminate the solution. After one month of the frst opening do not use the medicine of dropper.