Defera 500 mg | INDICATIONS AND USES

Deferiprone is indicated for the treatment of iron overload patients with thalassemia major when deferoxamine therapy is contraindicated or inadequate. Deferiprone therapy should be initiated and maintained by a physician experienced in the treatment of patients with thalassemia.

Defera 500 mg | PHARMACOLOGY

Deferiprone is a chelating agent with an affinity for ferric ion (iron III). Deferiprone binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. Deferiprone has a lower binding affinity for other metals such as copper, aluminum and zinc than for iron.

Defera 500 mg | DOSAGE & ADMINISTRATION

In adults and children over 6 years: this medicine may be given by mouth in doses of 25mg/kg three times daily. Doses above 100mg/kg daily are not recommended. Or, as directed by the registered physician.

Defera 500 mg | DRUG INTERACTIONS

The safety of concurrent use of Deferiprone and Vitamin C has not been formally studied. Based on the reported adverse interaction that can occur between deferoxamine and Vitamin C, caution should be used when administering concurrent Deferiprone and Vitamin C. It should not be given with aluminium containing antacids.

Defera 500 mg | SIDE EFFECTS

Gastrointestinal disorders such as diarrhoea, nausea, vomiting and abdominal pain are common during deferiprone treatment and may require temporary reduction in dose. A reddish brown discoloration of the urine is also common. Other adverse effects that have been reported include arthralgia and increased liver enzymes.

Defera 500 mg | USE DURING PREGNANCY AND LACTATION

Deferiprone is not recommended for use in pregnant & lactating women.

Defera 500 mg | PRECAUTIONS & WARNINGS

Deferiprone has been shown to cause neutropenia including agranulocytosis. The patients neutrophil count should be monitored every week. Caution is advised in patients with hepatic or renal impairment.

Defera 500 mg | THERAPEUTIC CLASS

Antidote preparations

Defera 500 mg | STORAGE CONDITIONS

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Defera 500 mg

Deferiprone

Medicine Description