Crezyme 325 mg

Crezyme 325 mg | INDICATIONS AND USES

Pancreatin is employed for the treatment of patients with

Chronic pancreatitis
Cystic fibrosis/Mucoviscidosis
Following partial or complete pancreatectomy
Total gastrectomy
Steatorrhea
Somatostatinoma
Celiac disease and
Other conditions associated with pancreatic insufficiency

Crezyme 325 mg | PHARMACOLOGY

Pancreatin is a preparation of Pancreatin, an extract from mammalian pancreas containing enzymes with Amylase, Protease and Lipase activity. It is designed to disintegrate in the alkaline medium of the duodenum where it releases the active enzyme components of Pancreatin (Amylase, Protease and Lipase). Amylase hydrolyzes dietary starch to yield maltose, maltoriose and a-dextrin. Protease cleaves peptide bonds in the center of proteins and polypeptides and forms amino acids and oligopeptides. Lipase hydrolyzes dietary triglycerides forming two molecules of fatty acid and a molecule of beta-monoglyceride. It converts not less than 25 times its weight of starch into soluble carbohydrates and not less than 25 times its weight of casein into proteoses within 5 mins, (equivalent to 150 times in 30 mins).

Crezyme 325 mg | DOSAGE & ADMINISTRATION

2-3 tablets to be swallowed whole with little water immediately after or during meal. Or as directed by the physician

Crezyme 325 mg | DRUG INTERACTIONS

Alkaline media will rupture the enteric coating. As such to prevent bursting out of the content in the stomach Pancreatin should not be used concurrently with antacid.

Crezyme 325 mg | SIDE EFFECTS

The most frequent side effects are gastrointestinal including nausea, vomiting and abdominal discomfort. Buccal and perianal soreness may occur, particularly in infants. Hypersensitivity reactions manifested by sneezing, lacrimation or skin rashes have been reported.

Crezyme 325 mg | USE DURING PREGNANCY AND LACTATION

Pancreatin should be given to a pregnant woman only if clearly needed. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Pancreatin is administered to a nursing mother.

Crezyme 325 mg | PRECAUTIONS & WARNINGS

Patients known to be allergic to animal protein should be treated with caution.

Crezyme 325 mg | THERAPEUTIC CLASS

Digestive Enzyme

Crezyme 325 mg | STORAGE CONDITIONS

Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.