Cosentyx 150 mg/ml

Cosentyx 150 mg/ml | INDICATIONS AND USES

Secukinumab is a human interleukin-17A antagonist indicated for the treatment of:

Moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy
Adults with active psoriatic arthritis (PsA)
Adults with active ankylosing spondylitis (AS)

Cosentyx 150 mg/ml | PHARMACOLOGY

Secukinumab is a human monoclonal antibody that targets IL-17A cytokine to downregulate inflammation in psoriasis, an autoimmune dermatological disease. The pathophysiology of psoriasis has not been fully established, however it is known that dysregulation of innate and adaptive immune responses plays part in the chronic inflammation associated with the disease. IL-17 represents is a six-membered family (IL-17A to F) of pleiotropic pro-inflammatory cytokines, expression of which is found to be elevated in psoriatic skin. These cytokines act on many different cell types and provide defense against different extracellular pathogens causing fungal or bacterial infections. IL-17 cytokines are produced by many cells involved in immune system defense, such as Th17, mast cells, neutrophils, and dendritic cells - all implicated in promoting inflammation. There is evidence linking IL-17 to pathogenesis of multiple autoimmune diseases including rheumatoid arthritis, spondyloarthritis, psoriasis, Crohn's disease, multiple sclerosis, and even atherosclerosis.

Cosentyx 150 mg/ml | DOSAGE & ADMINISTRATION

Plaque Psoriasis-1. Recommended dosage is 300 mg by subcutaneous injection at Weeks 0, 1, 2, 3, and 4 followed by 300 mg every 4 weeks. For some patients, a dose of 150 mg may be acceptable.Psoriatic Arthritis-1. For psoriatic arthritis patients with coexistent moderate to severe plaque psoriasis, use the dosage and administration for plaque psoriasis.2. For other psoriatic arthritis patients administer with or without a loading dosage. The recommended dosage:

With a loading dosage is 150 mg at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter
Without a loading dosage is 150 mg every 4 weeks
If a patient continues to have active psoriatic arthritis, consider a dosage of 300 mg.

Ankylosing Spondylitis-1. Administer with or without a loading dosage. The recommended dosage:

With a loading dosage is 150 mg at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter
Without a loading dosage is 150 mg every 4 weeks

Cosentyx 150 mg/ml | DRUG INTERACTIONS

Live vaccines should not be given with Secukinumab

Cosentyx 150 mg/ml | SIDE EFFECTS

Most common adverse reactions (greater than 1%) are nasopharyngitis, diarrhea, and upper respiratory tract infection.

Cosentyx 150 mg/ml | USE DURING PREGNANCY AND LACTATION

Pregnancy: Limited available human data with secukinumab use in pregnant women are insufficient to inform a drug associated risk of adverse developmental outcomes. In an embryo-fetal development study, no adverse developmental effects were observed in infants born to pregnant monkeys after subcutaneous administration of secukinumab during organogenesis at doses up to 30 times the maximum recommended human doseLactation: It is not known whether secukinumab is excreted in human milk or absorbed systemically after ingestion. There are no data on the effects of secukinumab on the breastfed child or the effects on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for secukinumab and any potential adverse effects on the breastfed child from secukinumab or from the underlying maternal condition.

Cosentyx 150 mg/ml | PRECAUTIONS & WARNINGS

Infections: Serious infections have occurred. Caution should be exercised when considering the use of secukinumab in patients with a chronic infection or a history of recurrent infection. If a serious infection develops, discontinue secukinumab until the infection resolves.Tuberculosis (TB): Prior to initiating treatment with secukinumab, evaluate for TB.Inflammatory Bowel Disease: Cases of inflammatory bowel disease were observed in clinical trials. Caution should be exercised when prescribing secukinumab to patients with inflammatory bowel disease.Hypersensitivity Reactions: If an anaphylactic reaction or other serious allergic reaction occurs, discontinue secukinumab immediately and initiate appropriate therapy.

Cosentyx 150 mg/ml | THERAPEUTIC CLASS

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis

Cosentyx 150 mg/ml | STORAGE CONDITIONS

Secukinumab Sensoready pens, prefilled syringes and vials must be refrigerated at 2ºC to 8ºC. Keep the product in the original carton to protect from light until the time of use. Do not freeze. To avoid foaming do not shake. Secukinumab does not contain a preservative; discard any unused portion.