Corangi 10 mg

Corangi 10 mg | INDICATIONS AND USES

Nicorandil is indicated for the prevention and long-term treatment of angina pectoris.

Corangi 10 mg | PHARMACOLOGY

Nicorandil dilates arterioles and large coronary arteries by opening the potassium channels, and stimulates guanylate cyclase causing venous vasodilatation. It therefore reduces preload and afterload, and improves coronary blood flow.

Corangi 10 mg | DOSAGE & ADMINISTRATION

Adult: The usual therapeutic range is 10 to 20 mg twice daily. The usual starting dose is 10 mg twice daily, in the morning and in the evening preferably, and should be titrated upwards in accordance with patients needs, response and tolerance up to 40 mg twice daily, if necessary. An even lower starting dose of 5 mg twice daily may be used in patients particularly prone to headache. Eldery: There are no special dosage requirements for elderly patients, but as with all medicines the lowest effective dose should be used. Nicorandil should be administered with care, using low starting dosages, in the elderly. Children: Not recommended. Nicorandil should be used with caution in patients with serious hepatic dysfunction.Hepatic Impairment: Dose reduction may be necessary.

Corangi 10 mg | DRUG INTERACTIONS

Although no pharmacological and/or pharmacokinetic interaction has been obsen/ed in animal and human studies with Nicorandil associated with beta-blockers, calcium antagonists, digoxin, a combination of digoxin/furosemide, rifampicin, and cimetidine, it is not excluded that the drug may nevertheless potentiate the effect of other vasodilators, tricyclic antidepressants and antihypertensive drugs administered concurrently, especially in combination with alcohol.

Corangi 10 mg | SIDE EFFECTS

Headache (especially on initiation, usually transitory); cutaneous vasodilation with flushing; nausea, vomiting, dizziness, weakness also reported; rarely oral ulceration and myalgia; at high dosage, reduction in blood pressure and/or increase in heart rate; angioedema, also reported.

Corangi 10 mg | USE DURING PREGNANCY AND LACTATION

Although animal studies have not shown any harmful effect of Nicorandil to the foetus, has not been studied in human pregnancy. Use in pregnant women requires that the anticipated benefit be weighed against possible hazard. It is not known whether the drug is excreted in human milk. Caution should be exercised when Nicorandil is administered to a nursing mother. Drug interactions: Although no pharmacological and/or pharmacokinetic interaction has been obsen/ed in animal and human studies with Nicorandil associated with beta-blockers, calcium antagonists, digoxin, a combination of digoxin/furosemide, rifampicin, and cimetidine, it is not excluded that the drug may nevertheless potentiate the effect of other vasodilators, tricyclic antidepressants and antihypertensive drugs administered concurrently, especially in combination with alcohol.

Corangi 10 mg | PRECAUTIONS & WARNINGS

Hypovolaemia, low systolic BP, acute pulmonary oedema, pregnancy. May impair ability to drive or operate machinery.

Corangi 10 mg | THERAPEUTIC CLASS

Potassium-channel activator

Corangi 10 mg | STORAGE CONDITIONS

Store in a cool and dry place, protected from light.