Clofranil 25 mg is a Product of the Generic Clomipramine Hydrochloride

What Is Clofranil 25 mg Indications and Uses?

Clomipramine Hydrochloride is used to treat-

Obsessive Compulsive Disorder (OCD)
Major Depressive Disorder (MDD)
Depression.

Pharmacology (Source, Chemical and Physical Composition) Of Clofranil 25 mg

Clomipramine Hydrochloride is an original tricyclic antidepressant, a member of the dibenzazepine group of compounds. It is presumed to influence obsessive and compulsive behaviors through it's effects on serotonergic neuronal transmission. The actual neurochemical mechanism is unknown but it has the capacity to inhibit the reuptake of serotonin (5-HT) which is thought to be important (like obsessions, compulsion) thus hampers social acquaintance.

Dosage And Administration of Clofranil 25 mg

Initial dose is 25 mg at bed time about a week, gradual increase of dose should not be exceeded more than 150 mg per day in adult and 75 mg per day in elderly patient. Dose can be given as divided form to reduce gastrointestinal disturbances. Not recommended for children.

Drug Interactions of Clofranil 25 mg

Medicines for depression, particularly-

MAOIs e.g. tranylcypromine, phenelzine, moclobemide;
SSRIs e.g. fluoxetine (or have taken within the last 3 weeks), fluvoxamine, paroxetine, sertraline;
SNaRIs e.g. venlafaxine; tricyclic and tetracyclic antidepressants e.g. amitriptyline, dothiepin, maprotiline
Diuretics, also known as ‘water tablets’, e.g. bendroflumethiazide, furosemide
Anaesthetics, used for the temporary loss of bodily sensation
Blood pressure lowering agents (Beta blockers), Anti-coagulants etc.

Side Effects of Clofranil 25 mg

The most frequent side effects are gastrointestinal disturbances, Headache, dizziness, nausea, constipation, dry mouth, increased sweating, shaking hands, tremor, difficulty in passing urine, problems with their eyes, feeling tired or sleepy, sexual disturbance, restlessness.

Use During Pregnancy and Lactation

No adequate well-controlled studies of safety for pregnancy. Limited data suggest that clomipramine is likely to be excreted in human breast milk. Although it has known risk of damage to fetus.

Precautions And Warnings for Clofranil 25 mg

Talk to your doctor or pharmacist before taking Clomipramine if you:

have ever had suicidal thoughts
suffer from epilepsy (fits)
have had a head injury or have suffered brain damage
are going to have electric shock therapy (ECT)
have other problems with your heart
have been told you have a low level of potassium in your blood (hypokalaemia). The doctor will need to treat this before you start taking clomipramine
have kidney disease
suffer from schizophrenia or other mental health conditions
have a blood disorder
have an overactive thyroid gland
have had severe constipation for a long time
have a tumour (cancer) of the adrenal gland (such as phaeochromocytoma or neuroblastoma)
liver disease
have low blood pressure
wear contact lenses

Therapeutic Class

Tricyclic & related anti-depressant drugs

Storage Conditions of It

Do not store above 30°C. Keep away from light and out of the reach of children.