Ciprox XR Tablet (Extended Release) XR Tablet 1000 mg is a Product of the Generic Ciprofloxacin

What Is Ciprox XR Tablet (Extended Release) XR Tablet 1000 mg Indications and Uses?

Ciprox XR is indicated for the treatment of single infection or mixed infections caused by two or more susceptible organisms. It can also be used for infections caused by organisms resistant to other antibiotics including Aminoglycosides, Penicillins and Cephalosporins. As antibacterial ... Read more Ciprox XR is indicated for the treatment of single infection or mixed infections caused by two or more susceptible organisms. It can also be used for infections caused by organisms resistant to other antibiotics including Aminoglycosides, Penicillins and Cephalosporins. As antibacterial concentrations of Ciprox XR are obtained in serum and body tissues as well as in the urine following administration by mouth, Ciprox XR has been suggested for use in the treatment of a wide range of infections caused by susceptible organisms including infections of the urinary, respiratory and gastrointestinal tracts, gonorrhoea and septicaemia. The extensive tissue penetration of Ciprox XR combined with its enhanced antibacterial activity (including antipseudomonal activity), enables Ciprox XR to be used alone (pending sensitivity results) or in combination with an Aminoglycoside or with beta lactam antibiotics for instance when severe neutropenia is present or with an antibiotic active against anaerobes where the presence of bacteroides fragilis is suspected. Ciprox XR is indicated for the treatment of the following infections caused by sensitive bacteria: Severe systemic infections: e.g. septicaemia, bacteraemia, peritionitis, infections in immunosuppressed patients with haematological or solid tumors and in patients in intensive care unit with specific problems such as infected burns. Respiratory tract infections: Lobar and bronchopneumonia, acute and chronic bronchitis, acute exacerbation of cystic fibrosis, bronchiectasis, empyema. Urinary tract infections: Uncomplicated and complicated urethritis, cystitis, pyelonephritis, prostatitis, epididymitis. Skin and soft tissue infections: e.g. infected ulcers, wound infections, abscesses, cellulitis, otitis externa, erysipelas, infected burns. Gastro-intestinal infections: e.g. enteric fever, infective diarrhea. Infection of the biliary tract: e.g. cholangitis, cholecystitis, empyema of the gall bladder. Intra abdominal infections: e.g. peritonitis, intra abdominal abscesses. Bone and joint infection: Osteomyelitis, septic arthritis. Pelvic infections: e.g. salpingitis, endometritis, pelvic inflammatory diseases. Eye, ear, nose and throat infections: e.g. otitis media, sinusitis, mastoiditis, tonsillitis. Gonorrhoea: Including urethral, rectal and pharyngeal gonorrhoea caused by beta-lactamase producing organisms or organisms moderately sensitive to penicillin.

Pharmacology (Source, Chemical and Physical Composition) Of Ciprox XR Tablet (Extended Release) XR Tablet 1000 mg

Ciprox XR Tablet (Extended Release) XR Tablet 1000 mg (Ciprofloxacin) is a synthetic quinolone anti-infective agent. Ciprofloxacion has broad spectrum of activity. It is active against most gram negative aerobic bacteria including Enterobacteriaceae and Pseudomonas aeruginosa. Ciprofloxacin is also active against gram-positive aerobic bacteria including penicillinase producing, non penicillinase producing, and methicillin resistant staphylococci, although many strains of streptococci are relatively resistant to the drug. The bactericidal action of Ciprofloxacin results from interference with the enzyme DNA gyrase needed for the synthesis of bacterial DNA. Following oral administration it is rapidly and well absorbed from the G.I. tract. It is widely distributed into the body tissues and fluids. The half life is about 3.5 hours. About 30% to 50% of an oral dose of Ciprofloxacin is excreted in the urine within 24 hours as unchanged drug and biologically active metabolites.

Drug Interactions of Ciprox XR Tablet (Extended Release) XR Tablet 1000 mg

Concurrent administration of Ciprox XR should be avoided with Magnesium or Aluminum containing antacids or sucralfate or with other products containing Calcium, Iron or Zinc. These products may be taken two hours after or six hours before Ciprox XR. Ciprox XR should not be taken concurrently with milk or other dairy products, since absorption of Ciprox XR may be significantly reduced. Dietary calcium is a part of a meal, however, does not significantly affect the absorption of Ciprox XR.

Side Effects of Ciprox XR Tablet (Extended Release) XR Tablet 1000 mg

Gastrointestinal disturbances e.g. nausea, diarrhoea, vomiting, dyspepsia, abdominal pain. Disturbances of the central nervous system e.g. headache, dizziness, tiredness, confusion, convulsion & risk of retinal detachment. Hypersensitivity reactions e.g. skin rash (very rarely Stevens-Johnson syndrome and toxic epidermal necrolysis), pruritus and possible systemic reactions. The other less reported reactions are joint pain, mild photosensitivity and transient increase in liver enzymes (particularly in patients with previous liver damage), serum bilirubin, urea or creatinine levels. Risk of hypoglycemia & mental health adverse effects.

Precautions And Warnings for Ciprox XR Tablet (Extended Release) XR Tablet 1000 mg

It should be used with caution in patients with suspected or known CNS disorders such as arteriosclerosis or epilepsy or other factors which predispose to seizures and convulsion. Ciprox XR may be taken with or without meals and to drink fluids liberally. Concurrent administration of Ciprox XR should be avoided with magnesium / aluminium antacids, or sucralfate or with other products containing calcium, iron and zinc. These products may be taken two hours after or six hours before Ciprox XR. Ciprox XR should not be taken concurrently with milk or yogurt alone, since absorption of Ciprox XR may be significantly reduced. Dietary calcium is a part of a meal, however, does not significantly affect the Ciprox XR absorption.

Use During Pregnancy and Lactation

Reproduction studies performed in mice, rats and rabbits using parenteral and oral administration did not reveal any evidence of teratogenicity, impairment of fertility or impairment of peri/post natal development. However as with other quinolones, Ciprox XR Tablet (Extended Release) XR Tablet 1000 mg (Ciprofloxacin) has been shown to cause arthropathy in immature animals and therefore its use during pregnancy is not recommended. Studies in rats have indicated that Ciprofloxacin is secreted in milk, administration to nursing mothers is thus not recommended.

Therapeutic Class

4-Quinolone preparations, Anti-diarrhoeal antimicrobial drugs

Storage Conditions of It

Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children. Pack Image: Ciprox XR 1000 mg XR Tablet Thanks for using MedEx! How would you rate your experience so far?