Cipran Capsule (Extended Release) XR Capsule 80 mg is a Product of the Generic Levomilnacipran Hydrochloride

Cipran Capsule (Extended Release) XR Capsule 80 mg belongs to the generic category of Levomilnacipran Hydrochloride. This medicine should be used according to a doctor's advice. We have provided detailed information about the uses, dosage, effectiveness, side effects, precautions, drug interactions, storage conditions, and other important details of Cipran Capsule (Extended Release) XR Capsule 80 mg. Our goal is to present essential medicine information in one place for patients, caregivers, and healthcare professionals. To better understand Levomilnacipran Hydrochloride and ensure the safe use of this medicine, please read the information below carefully and consult a healthcare professional when necessary.

Description of Cipran Capsule (Extended Release) XR Capsule 80 mg

Cipran Capsule (Extended Release) XR Capsule 80 mg may be available as a prescription or over-the-counter medicine, depending on local regulations and medical recommendations. It is used for the treatment and management of specific conditions or symptoms. The way this medicine is used may vary depending on the patient's condition and the advice of a healthcare provider. Detailed information about the approved uses, therapeutic applications, and other relevant details of Cipran Capsule (Extended Release) XR Capsule 80 mg is provided below to help users gain a clear understanding of this medicine.

What Is Cipran Capsule (Extended Release) XR Capsule 80 mg Indications and Uses?

Cipran is a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for the treatment of Major Depressive Disorder (MDD) in adults. Limitation of Use: Cipran is not approved for the management of fibromyalgia. The efficacy and safety of Cipran for the management of fibromyalgia have not been established.

Pharmacology (Source, Chemical and Physical Composition) Of Cipran Capsule (Extended Release) XR Capsule 80 mg

The exact mechanism of the antidepressant action of Cipran Capsule (Extended Release) XR Capsule 80 mg (Levomilnacipran Hydrochloride) is unknown, but is thought to be related to the potentiation of serotonin and norepinephrine in the central nervous system, through inhibition of reuptake at serotonin and norepinephrine transporters. Non-clinical studies have shown that levomilnacipran is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI). Levomilnacipran binds with high affinity to the human serotonin (5-HT) and norepinephrine (NE) transporters (Ki = 11 and 91 nM, respectively) and potently inhibits 5-HT and NE reuptake (IC50 = 16-19 and 11 nM, respectively). Levomilnacipran lacks significant affinity for any other receptors, ion channels or transporters tested in vitro, including serotonergic (5HT1-7), α- and β-adrenergic, muscarinic, or histaminergic receptors and Ca 2+ , Na + , K + or Cl - channels. Levomilnacipran did not inhibit monoamine oxidase (MAO).

Dosage And Administration of Cipran Capsule (Extended Release) XR Capsule 80 mg

Recommended dose : 40 mg to 120 mg once daily with or without food. Initiate dose at 20 mg once daily for 2 days and then increase to 40 mg once daily. Based on efficacy and tolerability, increase dose in increments of 40 mg at intervals of 2 or more days. The maximum recommended dose is 120 mg once daily. Take capsules whole; do not open, chew or crush. Renal Impairment : Do not exceed 80 mg once daily for moderate impairment. Do not exceed 40 mg once daily for severe renal impairment. Discontinuation : Reduce dose gradually whenever possible.

Drug Interactions of Cipran Capsule (Extended Release) XR Capsule 80 mg

Strong CYP3A4 inhibitors such as ketoconazole: Do not exceed 80 mg once daily.

Side Effects of Cipran Capsule (Extended Release) XR Capsule 80 mg

Hypersensitivity Suicidal Thoughts and Behaviors in Adolescents and Young Adults Serotonin Syndrome Elevated Blood Pressure Elevated Heart Rate Increased Risk of Bleeding Angle Closure Glaucoma Urinary Hesitation or Retention Activation of Mania/Hypomania Seizure Discontinuation Syndrome Hyponatremia

Use During Pregnancy and Lactation

Pregnancy: Third trimester use may increase risk for symptoms of poor adaptation (respiratory distress, temperature instability, feeding difficulty, hypotonia, tremor, irritability) in the neonate.

Therapeutic Class

Serotonin-norepinephrine reuptake inhibitor (SNRI)

Storage Conditions of It

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children. Pack Image: Cipran 80 mg XR Capsule Thanks for using MedEx! How would you rate your experience so far?