Biocef 500 mg is a Product of the Generic Cefaclor Monohydrate

Indications of Biocef
Biocef 100 ml Powder For Suspension is indicated for the treatment of the following infections: Otitis media, Infections of the lower respiratory tract, including pneumonia, bronchitis and exacerbation of chronic bronchitis, Infections of the upper respiratory tract, including pharyngitis and tonsillitis, Infections of the urinary tract, including pyelonephritis and cystitis, Skin and soft tissue infections, sinusitis



Pharmacology
Cefaclor is a second generation cephalosporin antibiotic that is stable against blactamase inactivation and has a broad spectrum of activity. Cefaclor has in vitro activity against the following organisms: alpha and beta hemolytic streptococci, staphylococci; including coagulase-positive, coagulase-negative and penicillinase-producing strains, Streptococcus pneumoniae, Streptococcus pyogenes (group A hemolytic streptococcus), Branhamella catarrhalis, Escherichia coli, Proteus mirabilis, Klebsiella species Haemophilus influillenzae, including tube-resistant strains injection. Cefaclor is generally effective in eradicating streptococci from the nasopharynx.



Pharmaceutical Name of Biocef
Novartis(Bangladesh) Limited



Dosage
Adults

Usual dose: 250 mg 8 hours.
Bronchitis & Pneumonia: 250 mg tid.
Sinusitis: injection of 500 mg for 10 days.
Pneumonia and more severe infections: Maximum: 4 g / day for 28 days.
Acute gonococcal urethritis: 3 g as a single dose in combination with 1 g of probenecid.
Children

Recommended dose: 20 mg / kg / day in divided doses every 8 hours.
Bronchitis and pneumonia: 20 mg / kg / day in divided doses.
Serious infections, sinusitis, otitis media and infections: caused by less susceptible organisms 40 mg / kg / day in divided doses. Maximum: 1 g / day.


Administration
May be taken with or without food.



Interaction
The nephrotoxicity of aminoglycoside antibiotics such as gentamicin and tobramycin can be enhanced by any cephalosporin. Therefore, care should be taken when these drugs are used concomitantly.



Contraindications
Cefaclor is contraindicated in patients allergic to the cephalosporin group of antibiotics.



Effects
Digestive System: Diarrhea, nausea and vomiting have been reported.

Hypersensitivity: Allergic reactions such as rash, pruritus and hives have been observed. These reactions usually go away when treatment is stopped. A serum sickness-like reaction has been reported.

Hematologic: Eosinophilia, thrombocytopenia, transient lymphocytosis and leukopenia may occur in rare cases.

Hepatic: Transient hepatitis and cholestatic jaundice, with slight increases in AST, ALT or alkaline phosphate values ​​have been reported rarely.

Renal: Reversible interstitial nephritis is rare, with a slight increase in blood urea or serum creatinine or an abnormal urinalysis.

Central nervous system: Reversible hyperactivity, nervousness, confusion, asthenia, dizziness, hallucinations and drowsiness have been reported rarely.



Pregnancy & Lactation
There are no adequate and well-controlled studies in pregnant women. This medicine should be used during pregnancy only if clearly needed. Small amounts of Cefaclor have been detected in breast milk. Effects on breastfed infants are not known. Caution should be exercised when administering Cefaclor to a nursing woman.



Precautions & Warnings
Cefaclor should be used with caution in patients with marked renal impairment. No dosage adjustment is usually necessary in patients with moderate or severe renal impairment.



Therapeutic Class
Second generation Cephalosporins



Storage Conditions
Store in a cool and dry place. Protect from light.