Binoclar 60 ml

Indications of Binoclar 60 ml Powder for Suspension
Clarithromycin is indicated in-

Streptococcal pharyngitis
Sinusitis
Infective exacerbations of chronic bronchitis
Community-acquired pneumonia
Atypical pneumonia
Skin and soft tissue infection
Adjunct in the treatment of duodenal ulcers by eradication of H.pylori.


Pharmacology of Binoclar 60 ml Powder for Suspension
The role of clarithromycin is primarily to inhibit microsomal protein binding in fragile organisms by having authority over the donor position on the 50S subunit of the bacterial ribosome and the expected translocation to this position. Clarithromycin has a dynamic effect on most gram-positive organisms and chlamydia, some gram-negative organisms, and mycoplasmas. The effect of clarithromycin against most gram-positive organisms in vitro is the same or more remarkable as that of erythromycin. Clarithromycin is more acid resistant than erythromycin, so it is better tolerated. The effect of clarithromycin on Helicobacter pylori is twice that of erythromycin. Flu. Due to the inability to enter the target, most gram-negative organisms are safe for clarithromycin.



Dosage of Binoclar 60 ml Powder for Suspension
Adults:

Pharyngitis / Tonsillitis 250 mg every 12 hours for 10 days.
Acute maxillary sinusitis 500 mg every 12 hours for 14 days.
Chronic bronchitis 250-500 mg every 12 hours for 7-14 days.
Pneumonia 250 mg every 12 hours for 7-14 days.
Uncomplicated skin & skin structure infections 250 mg every 12 hours for 7-14 days.
Community-acquired upper and lower respiratory tract infections 250-500 mg every 12 hours for 5-14 days.
Children:

Bodyweight under 8 kg: 7.5 mg/kg twice daily.
Bodyweight of 8-11 kg (1-2 years): 2.5 ml (Half teaspoonful) twice daily.
Bodyweight of 12-19 kg (3-6 years): 5 ml (One teaspoonful) twice daily.
Bodyweight of 20-29 kg (7-9 years): 7.5 ml (One & half teaspoonfuls) twice daily.
Bodyweight of 30-40 kg (10-12 years): 10 ml (Two teaspoonfuls) twice daily.


Administration of Binoclar 60 ml Powder for Suspension
Clarithromycin may be given with or without meals.



Interaction of Binoclar 60 ml Powder for Suspension
Clarithromycin and Theophylline: Taking Clarithromycin and Theophylline at the same time may cause a rise in serum Theophylline levels. Terfenadine: Clarithromycin may affect Terfenadine metabolism.



Contraindications
Extreme touchiness to Clarithromycin, Erythromycin, or any of the macrolide anti-microbials. Patients getting Terfenadine who have pre-existing cardiac variations from the norm or electrolyte unsettling influences.



Side Effects of Binoclar 60 ml Powder for Suspension
Clarithromycin is by and large well endured. Side impacts incorporate queasiness, heaving, the runs and stomach torment. Stomatitis and glossitis have too been detailed. Other side impacts incorporate migraine, unfavorably susceptible responses extending from urticaria and gentle skin responses to anaphylaxis. Taste corruption may happen. There have been reports of transitory central anxious framework side impacts counting uneasiness, tipsiness, sleep deprivation and visualization.



Pregnancy & Lactation
In proper doses, the medication can be utilized in newborns and children. Infants should not be fed breast milk from mothers who are on Clarithromycin until their treatment is finished. Clarithromycin is not suggested because there is currently insufficient experience with the treatment of pregnant individuals.



Precautions & Warnings
The liver and kidneys are the main excretion organs for clarithromycin. Patients with compromised hepatic and renal function should be given this antibiotic with caution. The usage of Clarithromycin for an extended period of time or on a regular basis can lead to an overgrowth of non-susceptible bacteria or fungi. If a superinfection develops, Clarithromycin should be stopped and appropriate treatment started.



Therapeutic Class
Macrolides.



Storage Conditions
Store in a cool, dry location away from light and moisture. If maintained at room temperature, the reconstituted suspension must be used within 7 days; if kept in the refrigerator, it must be used within 14 days. Keep out of children's reach.



Pharmaceutical Name of Binoclar 60 ml Powder for Suspension
Novartis Bangladesh



Generic of Binoclar 60 ml Powder for Suspension