Becosules Gold N/A

INDICATIONS

This combination capsule is indicated in the treatment of patients with deficiencies of, or increased requirement for, vitamin B-complex and vitamin C. Such patients and conditions include:

Decreased intake because of restricted or unbalanced diet as in anorexia, diabetes mellitus, obesity and alcoholism. ... Read moreThis combination capsule is indicated in the treatment of patients with deficiencies of, or increased requirement for, vitamin B-complex and vitamin C. Such patients and conditions include:

Decreased intake because of restricted or unbalanced diet as in anorexia, diabetes mellitus, obesity and alcoholism.
Reduced availability during treatment with antimicrobials which alter normal intestinal flora, in prolonged diarrhea and in chronic gastrointestinal disorders.
Increased requirements due to increased metabolic rate as in fever and tissue wasting, e.g. febrile illness, acute or chronic infections, surgery, burns and fractures.
Stomatitis, glossitis, cheilosis, paraesthesias, neuralgia and dermatitis.
Micronutrient deficiencies during pregnancy or lactation.

PHARMACOLOGY

Vitamin B-Complex and Vitamin C function as cofactors of various enzymes which regulate carbohydrate, protein and fat metabolism.Thiamine (B1) acts as a cofactor in the decarboxylation of keto acids such as pyruvic acid.Riboflavin (B2) plays a vital role in cellular respiratory reactions in conjunction with nicotinamide.Pyridoxine (B6) takes part in decarboxylation and interconversion of amino acids. It is also required for normal antibody-mediated and cell-mediated immune responses.Vitamin B12 (cyanocobalamin) is required for synthesis of DNA (deoxyribo-nucleic acid) and maturation of RBCs (red blood cells). Nicotinamide plays a vital role in cellular respiration in conjunction with riboflavin.Calcium Pantothenate functions as a cofactor for enzymes involved in transfer of acetyl groups. It is also required for normal antibody response in conjunction with pyridoxine.Folic acid, after conversion in the body to folinic acid, takes part in reactions involved in the synthesis of nucleotides and maturation of RBCs in conjunction with vitamin B12. It also plays an important role in lymphocyte-mediated immune response.Ascorbic acid (Vitamin C) takes part in biochemical reactions involving oxidation, as in collagen synthesis, and in conversion of folic acid to folinic acid. It is also necessary for normal phagocytic function ofWBCs (white blood cells).Thus an adequate supply of these water-soluble vitamins is required for the optimum function of various cells and tissues.Except for Vitamin B12, these water-soluble vitamins are not stored in the body to any significant extent, the excess quantities being excreted in the urine. Therefore, a regular and adequate intake of them is necessary to meet the metabolic requirements. Deficiencies of water-soluble vitamins often co-exist because of their overlapping dietary sources and metabolic interdependence. Initially the deficiency of these vitamins may be subclinical and demonstrable only by means of biochemical tests. If not corrected at this stage, it may become manifest as various symptoms, including impaired wound healing and increased susceptibility to infection. Classical deficiency diseases such as beri beri, pellagra and scurvy are rare, whereas mild and subclinical deficiencies are probably more common, even among apparently healthy individuals.

DOSAGE & ADMINISTRATION

One capsule daily or as advised by the physician.

INTERACTION

Folic acid may lower the serum concentration of phenytoin. Pyridoxine can reduce the effect of levodopa.

SIDE EFFECTS

Allergic reactions may occur in patients hypersensitive to any component in the preparation, for example,methyl parahydroxybenzoate or thiamine. There have been rare reports of anaphylactoid reactions following repeated injection of preparations containing thiamine. Flushing, itching or burning of the skin may occur in patients susceptible to the effects of nicotinamide.

PREGNANCY & LACTATION

Animal reproduction studies or clinical investigations during pregnancy have not been carried out with thispreparation. However, there are published reports on safe administration of water-soluble vitamins in this patient group.

PRECAUTIONS & WARNINGS

Patients with deficiency or increased requirement of Vitamin B-complex and Vitamin C should be accompanied by specific therapy for the primary illness. Treatment with capsule should be continued only until the deficiency is corrected or the need for supplementation exists. Pyridoxine may reduce the therapeutic effects of levodopa in Parkinson's disease, Riboflavin may color the urine yellow. During treatment with capsule the urine may give a false positive result for sugar by Benedict's test because of the presence of ascorbic acid. Therefore, a test not affected by ascorbic acid should be used.

THERAPEUTIC CLASS

Specific combined vitamin preparations

STORAGE CONDITIONS

Store in a cool and dry place, away from light and children.