Azinil Ophthalmic Solution Eye Drop 0.01 is a Product of the Generic Azithromycin Dihydrate

What Is Azinil Ophthalmic Solution Eye Drop 1% Indications and Uses?

Azinil Eye Drops is indicated for the treatment of bacterial conjunctivitis caused by CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, and Streptococcus pneumonia.

Pharmacology (Source, Chemical and Physical Composition) Of Azinil Ophthalmic Solution Eye Drop 1%

Azinil Ophthalmic Solution Eye Drop 1% (Azithromycin Dihydrate) is acid-stable and can therefore be taken orally with no need of protection from gastric acids. It is readily absorbed; its absorption is greater on an empty stomach. Time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms. Due to the high concentration in phagocytes, azithromycin is actively transported to the site of infection. During active phagocytosis, large concentrations of azithromycin are released. The concentration of azithromycin in the tissues can be over 50 times higher than in plasma. This is due to ion trapping and the high lipid solubility. Azithromycin's half-life allows a large single dose to be administered and yet maintain bacteriostatic levels in the infected tissue for several days. Following a single 500 mg dose, plasma concentrations of azithromycin declined in a polyphasic pattern with a mean apparent plasma clearance of 630 mL/min and a terminal elimination half life of 68 hours. The prolonged terminal half-life is thought to be due to extensive uptake and subsequent release of drug from tissues. Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination. Over the course of a week, approximately 6% of the administered dose appears as unchanged drug in urine. Microbiology: Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and, thus, interfering with microbial protein synthesis. Nucleic acid synthesis is not affected. Azithromycin has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections: Aerobic and facultative gram-positive microorganisms: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes Aerobic and facultative gram-negative microorganisms: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae Other microorganisms: Chlamydia pneumoniae, Chlamydia trachomatis , Mycoplasma pneumoniae , Betalactamase production should have no effect on azithromycin activity. Aerobic and facultative gram-positive microorganisms: Streptococci (Groups C,F,G), Viridans group streptococci Aerobic and facultative gram-negative microorganisms: Bordetella pertussis, Legionella pneumophila Anaerobic microorganisms: Peptostreptococcus species, Prevotella bivia

Dosage And Administration of Azinil Ophthalmic Solution Eye Drop 1%

Children of one year of age and adults : Instill 1 drop in affected eye(s) twice daily for the first 2 days then once daily for the next 5 days. Pediatric Use : The safety and effectiveness of Azinil Ophthalmic Solution Eye Drop 1% (Azithromycin Dihydrate) Eye Drops in pediatric patients below 1 year of age have not been established. Children less than one year of age : Not recommended.

Drug Interactions of Azinil Ophthalmic Solution Eye Drop 1%

Drug interaction studies have not been conducted with Azinil Eye Drops.

Side Effects of Azinil Ophthalmic Solution Eye Drop 1%

Eye irritation, contact dermatitis, corneal erosion, dry eye, punctate keratitis etc.

Precautions And Warnings for Azinil Ophthalmic Solution Eye Drop 1%

Azinil Eye Drops is indicated for topical ophthalmic use only and should not be administered systemically, injected subconjunctivally, or introduced directly into the anterior chamber of the eye.

Use During Pregnancy and Lactation

Pregnancy Category B. In the animal studies, no evidence of harm to the fetus due to Azinil Ophthalmic Solution Eye Drop 1% (Azithromycin Dihydrate) was found. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Azithromycin should be used during pregnancy only if clearly needed. It is not known whether Azithromycin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Azithromycin is administered to a nursing woman.

Therapeutic Class

Macrolides

Storage Conditions of It

Store unopened bottle under refrigeration at 2°C to 8°C. Once the bottle is opened, store it at 25°C for up to 14 days. Discard after the 14 days of opening. Thanks for using MedEx! How would you rate your experience so far?