Asmaloc 120 mg/5 ml is a Product of the Generic Theophylline

What Is Asmaloc 120 mg/5 ml Indications and Uses?

Asmaloc 120 mg/5 ml (Theophylline) is indicated for the- Control of acute asthma. Management of chronic asthma (For both Symptomatic and prophylactic treatment). For controlling nocturnal asthma and early morning wheezing. Management of chronic obstructive lung disease (Chronic bronchitis and emphysema) and acute exacerbation of chronic obstructive lung disease. Control of apnea of prematurity.

Pharmacology (Source, Chemical and Physical Composition) Of Asmaloc 120 mg/5 ml

Asmaloc 120 mg/5 ml (Theophylline) is a bronchodilator, structurally classified as a Methylxanthine. Theophylline has two distinct actions in the airways of patients with reversible obstruction; smooth muscle relaxation and suppression of the response of the airways to stimuli. Theophylline also increases the force of contraction of diaphragmatic muscles. The half-life of Theophylline is influenced by a number of known variables. In adult nonsmokers with uncomplicated asthma the half-life ranges from 3 to 9 hours

Dosage And Administration of Asmaloc 120 mg/5 ml

The dose of Asmaloc 120 mg/5 ml (Theophylline) must be individualized on the basis of peak serum theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects. Most of the sustained release preparations may be administered every 12 hours in adults while administration every 8 hours may be necessary in some children with markedly rapid hepatic metabolism of theophylline. The recommended maintenance dose within accepted therapeutic range is as follows: 16 years or older: 10 mg/Kg/day (Do not exceed 900 mg/day) 12 years-15 years: 13 mg/Kg/day 9-11 years: 16 mg/Kg/day 1 year-8 years: 24-24 mg/Kg/day 6 months-1 year: 12-18 mg/Kg/day 1-6 months: 10 mg/Kg/day. Pediatrics use : The clearance of Theophylline is very low in neonates. Careful attention to dosage selection and monitoring of serum Theophylline concentrations are required in pediatric patients.

Drug Interactions of Asmaloc 120 mg/5 ml

Asmaloc 120 mg/5 ml (Theophylline) should not be used concurrently with other preparations containing xanthine derivatives. The clearance of Asmaloc is increased by barbiturates, carbamazepine, lithium, phenytoin, rifampicin and sulphinpyrazone and it may therefore be necessary to increase dosage. On the other hand, the clearance of the drug is reduced by allopurinol, cimetidine, ciprofloxacin, corticosteroids, erythromycin, frusemide, isoprenaline, oral contraceptive and thiabendazole and a reduced dosage may therefore be needed to avoid side effects. Asmaloc can potentiate hypokalemia resulting from beta-2-agonist therapy, steroids, diuretics and hypoxia, so serum potassium levels should be monitored in such instances.

Side Effects of Asmaloc 120 mg/5 ml

Generally side effects are rare at normal dosage. It may include gastrointestinal discomfort, headache, nausea, insomnia and hypotension. CNS stimulation and diuresis may also occur, especially in children.

Precautions And Warnings for Asmaloc 120 mg/5 ml

Careful consideration is needed for various interacting drugs and physiologic conditions that can alter Asmaloc 120 mg/5 ml (Theophylline) clearance. Dosage adjustment is required prior to initiation of Asmaloc therapy, prior to increases in Asmaloc dose, and during follow up. The dose of Asmaloc selected for initiation of therapy should be low and, if tolerated, increased slowly over a period of time.

Use During Pregnancy and Lactation

It is not known whether Asmaloc 120 mg/5 ml (Theophylline) can cause foetal harm when administered to pregnant woman. Xanthines should be given to a pregnant woman only if clearly needed. Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants. Serious adverse effects in the infant are unlikely unless the mother has toxic serum Theophylline concentrations.

Therapeutic Class

Bronchodilator, Theophylline & related drugs

Storage Conditions of It

Keep all medicines out of reach of children. Store in a cool and dry place, protected from light. Thanks for using MedEx! How would you rate your experience so far?